{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:04:39Z","timestamp":1791504279191,"version":"4.3.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Comprising nearly 35% of brain lipids, polyunsaturated fatty acids (PUFA) are essential for optimal brain function. However, the role of PUFA on cognitive health outcomes later in life is largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated prospective associations of plasma phospholipid omega-3 (ALA [18\u200a:\u200a3], EPA [20\u200a:\u200a5], DPA [22\u200a:\u200a5], DHA [22\u200a:\u200a6]) and omega-6 (LA [18\u200a:\u200a2], AA [20\u200a:\u200a4]) PUFA with cognitive decline, risk of cognitive impairment and dementia among adults aged\u226565 years in the Cardiovascular Health Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Circulating fatty acid concentrations were measured serially at baseline (1992\/1993), 6 years, and 13 years later. Cognitive decline and impairment were assessed using the 100-point Modified Mini-Mental State Examination (3MSE) up to 7 times. Clinical dementia was identified using adjudicated neuropsychological tests, and ICD-9 codes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 3,564 older adults free of stroke and dementia at baseline, cognitive function declined annually by approximately -0.5 3MSE points; 507 participants developed cognitive impairment and 499 dementia over up to 23 years of follow-up. In multivariable models, higher circulating arachidonic acid (AA) concentrations were associated with slower cognitive decline and lower dementia risk, with associations growing stronger with greater length of follow-up (hazard ratio [HR,95% CI] of dementia per interquintile range, 0.74 [0.56-0.97] at 5 years, and 0.53 [0.37-0.77] at 15 years). Circulating docosapentaenoic (DPA) concentrations were associated with slower cognitive decline and lower risk of cognitive impairment (extreme-quintile HR, 0.72 [95% CI: 0.55, 0.95]). Findings were generally null or inconsistent for other omega-3 or omega-6 PUFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Circulating AA and DPA, but not other PUFA, are associated with slower rate of cognitive decline and lower risk of dementia or cognitive impairment later in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230083","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:49:57Z","timestamp":1692960597000},"page":"965-979","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Circulating Omega-3 and Omega-6 Fatty Acids, Cognitive Decline, and Dementia in Older Adults"],"prefix":"10.1177","volume":"95","author":[{"given":"Marcia C.","family":"de Oliveira Otto","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Human Genetics and Environmental Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health and the Faculty of Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan L.","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Public Health, Brigham Young University, Provo, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Tsz Mung","family":"Lai","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA"},{"name":"Department of Primary Care and Public Health, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn N.","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Padhye","sequence":"additional","affiliation":[{"name":"Center for Nursing Research, The University of Texas Health Science Center, School of Nursing, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Song","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena B.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburg School of Medicine, Pittsburg, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[{"name":"New York Academy of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariush","family":"Mozaffarian","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.059"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990140"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.07.019"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2421"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.8.911"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002087"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(98)00055-2"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(91)90005-W"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009849"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4067"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz005"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020646"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.22844"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.316533"},{"key":"ref015","doi-asserted-by":"crossref","unstructured":"WillettWC, StampferM (1998) Issues in analysis and presentation of diatary data. 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