{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:22:31Z","timestamp":1792113751566,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer\u2019s disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65\u201375 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of rs6859 A allele, but not in non-carriers. We conclude that pneumococcal polysaccharide vaccine is a promising candidate for genotype-tailored AD prevention.<\/jats:p>","DOI":"10.3233\/jad-230088","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:43:27Z","timestamp":1696333407000},"page":"499-505","source":"Crossref","is-referenced-by-count":19,"title":["Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"96","author":[{"given":"Svetlana","family":"Ukraintseva","sequence":"first","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Duan","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Simanek","sequence":"additional","affiliation":[{"name":"Department of Foundational Sciences and Humanities, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Holmes","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Bagley","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind L.","family":"Rajendrakumar","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arseniy P.","family":"Yashkin","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Akushevich","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tropsha","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Whitson","sequence":"additional","affiliation":[{"name":"Center for Aging and Human Development, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoliy","family":"Yashin","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Arbeev","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230088_ref1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fgene.2018.00362","article-title":"Role of microbes in the development of Alzheimer\u2019s disease: State of the art - 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