{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:09:27Z","timestamp":1777396167380,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Depression and dementia confer substantial global health burdens, particularly in women. Understanding the association between depression and dementia may inform new targets for prevention and\/or early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association between depression in mid- and later-life and dementia (all-cause, Alzheimer\u2019s disease (AD) or vascular dementia (VaD)) in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective study design. Nurses were followed from age 60 years or entry into the cohort, whichever came last, until date of dementia, death, emigration, or end of follow-up, whichever came first. Cox regression models with age as the underlying timeline were used to estimate the associations between time-varying depression and incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included 25,651 female Danish nurses (\u226545 years) participating in the Danish Nurse Cohort. During an average of 23 years of follow-up, 1,232 (4.8%) nurses developed dementia and 8,086 (31.5%) were identified with at least two episodes of treated depression. In adjusted analyses, nurses with depression were at a statistically significant 5.23-fold higher risk of all-cause dementia (aHR 5.23:95% CI, 4.64\u20135.91) compared to those with no history of depression. The differential effects of depression were greater for VaD (aHR 7.96:95% CI, 5.26\u201312.0) than AD (aHR 4.64:95% CI, 3.97\u20135.42). Later life depression (&gt;60 years) (aHR 5.85:95% CI, 5.17\u20136.64) and recurrent depression (aHR 3.51:95% CI, 2.67\u20134.61) elevated dementia risk. Severe depression tripled the risk of all cause dementia (aHR 3.14:95% CI, 2.62\u20133.76).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both later life and severe depression substantially increase dementia risk in women, particularly VaD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230091","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T12:04:12Z","timestamp":1681819452000},"page":"779-789","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Depression in Mid- and Later-Life and Risk of Dementia in Women: A Prospective Study within the Danish Nurses Cohort"],"prefix":"10.1177","volume":"93","author":[{"given":"Martha","family":"Hickey","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Melbourne and the Royal Women\u2019s Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine K.","family":"Hueg","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and ChildHealth (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e6rke","family":"Priskorn","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and ChildHealth (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilie S.","family":"Uldbjerg","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and ChildHealth (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid L.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and ChildHealth (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaarin J.","family":"Anstey","sequence":"additional","affiliation":[{"name":"UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia"},{"name":"Neuroscience Research Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn-Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark"},{"name":"Seoul National University Medical Research Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira V.","family":"Br\u00e4uner","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and ChildHealth (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"ref001","unstructured":"World Health Organization (2019) Risk reduction of cognitive decline and dementia: WHO Guidelines. 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