{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:11:24Z","timestamp":1785532284954,"version":"3.56.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,5,30]]},"abstract":"<jats:p>Background: Brain iron homeostasis is disrupted in neurodegeneration and areas of iron overload partially overlap with regions of amyloid and tau burden in Alzheimer\u2019s disease (AD). Previous studies demonstrated alterations in brain iron accumulation in AD using quantitative susceptibility mapping (QSM). Objective: Here, we investigate brain alterations of QSM values in AD and non-AD patients as compared to healthy controls (HC) in the superior temporal sulcus and its banks (BANKSSTS), one of the top AD-affected regions. Methods: Thirty-four patients who underwent brain MRI including a multi-echo gradient-echo sequence were subdivided into AD (n\u200a=\u200a19) and non-AD (n\u200a=\u200a15) groups according to their clinical profile, CSF (A\u03b242\/40) and\/or amyloid-PET status. Ten HC were also included. QSM values were extracted from left and right BANKSSTS and compared among groups. Correlation and binomial regression analyses between QSM values and CSF-AD biomarkers were conducted. Results: QSM in left BANKSSTS was significantly different among groups (p\u200a=\u200a0.003, H\u200a=\u200a11.40), being higher in AD. QSM values in left BANKSSTS were correlated with A\u03b242 (rho \u20130.55, p\u200a=\u200a0.005), A\u03b242\/40 (rho \u20130.66, p\u200a&lt;\u200a0.001), pTau (rho 0.63, p\u200a&lt;\u200a0.001), tTau (rho 0.56, p\u200a=\u200a0.005), tTau\/A\u03b242 (rho 0.68, p\u200a&lt;\u200a0.001) and pTau\/A\u03b242 (rho 0.71, p\u200a&lt;\u200a0.001). No correlations between QSM values and amyloid-PET SUVR in the left BANKSSTS were found. QSM values in left BANKSSTS showed good accuracy in discriminating AD (AUC\u200a=\u200a0.80, CI95\u00a0% [0.66\u20130.93]). Higher QSM values were independent predictors of A\u03b242 (B\u200a=\u200a0.63, p\u200a=\u200a0.032), A\u03b242\/40 (B\u200a=\u200a0.81, p\u200a=\u200a0.028), pTau (B\u200a=\u200a0.96, p\u200a=\u200a0.046), tTau (B\u200a=\u200a0.55, p\u200a=\u200a0.027), and tTau\/A\u03b242 (B\u200a=\u200a1.13, p\u200a=\u200a0.042) positivity. Conclusion: Our preliminary data support the potential role of increased QSM values in the left BANKSSTS as an auxiliary imaging biomarker in AD diagnosis.<\/jats:p>","DOI":"10.3233\/jad-230095","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T06:49:59Z","timestamp":1683701399000},"page":"1125-1134","source":"Crossref","is-referenced-by-count":7,"title":["Banks of the Superior Temporal Sulcus in Alzheimer\u2019s Disease: A Pilot Quantitative Susceptibility Mapping Study"],"prefix":"10.1177","volume":"93","author":[{"given":"Luca","family":"Sacchi","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Elisa","family":"Contarino","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Siggillino","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Carandini","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Giulio","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Center For Mind\/Brain Sciences-CIMeC, University of Trento, Rovereto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Margherita","family":"Pietroboni","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Arcaro","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Orunesu","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Castellani","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milan, 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