{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:12:08Z","timestamp":1777396328063,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:p>Background: Preserving activities of daily living (ADL) is the key issue for Alzheimer\u2019s disease (AD) patients and their caregivers. Objective: To clarify the ADL level of AD patients at diagnosis and the risk factors associated with decreased ADL during long-term care (\u22643 years). Methods: Medical records of AD patients in a Japanese health insurance claims database were analyzed retrospectively to determine ADL using the Barthel Index (BI) and identify the risk factors associated with decreased ADL. Results: A total of 16,799 AD patients (mean age at diagnosis: 83.6 years, 61.5% female) were analyzed. Female patients were older (84.6 versus 81.9 years; p\u200a&lt;\u200a0.001) and had lower BI (46.8 versus 57.6; p\u200a&lt;\u200a0.001) and body mass index (BMI) (21.0 versus 21.7\u200akg\/m2; p\u200a&lt;\u200a0.001) than male patients at diagnosis. Disability (BI\u226460) increased at age\u226580 years and was significantly higher in females. Complete disability was most frequent for bathing and grooming. Risk factors for decreased ADL were determined separately by sex through comparing the ADL-preserved and ADL-decreased groups using propensity score matching by age and BI and multivariable logistic regression analysis. In males, decreased ADL was significantly associated with BMI\u200a&lt;\u200a21.5\u200akg\/m2, stroke, and hip fracture, and inversely associated with hyperlipidemia. In females, decreased ADL was significantly associated with BMI\u200a&lt;\u200a21.5\u200akg\/m2 and vertebral and hip fractures, and inversely associated with lower back pain. Conclusion: AD patients with low BMI, stroke, and fractures had increased risks of decreased ADL; such patients should be identified early and managed appropriately, including rehabilitation to preserve ADL.<\/jats:p>","DOI":"10.3233\/jad-230106","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:20:22Z","timestamp":1688124022000},"page":"1465-1475","source":"Crossref","is-referenced-by-count":5,"title":["Nationwide Database Analysis of Risk Factors Associated with Decreased Activities of Daily Living in Patients with Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"94","author":[{"given":"Keishi","family":"Akada","sequence":"first","affiliation":[{"name":"Human Biology Integration Foundation, Deep Human Biology Learning, Eisai Co. Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Government Relations Strategy Department, Eisai Co. Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Miura","sequence":"additional","affiliation":[{"name":"Human Biology Integration Foundation, Deep Human Biology Learning, Eisai Co. Ltd., Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Human Biology Integration Foundation, Deep Human Biology Learning, Eisai Co. Ltd., Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Aoshima","sequence":"additional","affiliation":[{"name":"Microbes & Host Defense Domain, Deep Human Biology Learning, Eisai Co. 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