{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:16:04Z","timestamp":1788131764151,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Background: Subjective cognitive decline (SCD) was proposed to identify older adults who complain about their memory but perform within a normal range on standard neuropsychological tests. Persons with SCD are at increased risk of dementia meaning that some SCD individuals experience subthreshold memory decline due to an underlying progression of Alzheimer\u2019s disease (AD). Objective: Our main goal was to determine whether hippocampal volume and APOE4, which represent typical AD markers, predict inter-individual differences in memory performance among SCD individuals and can be used to identify a meaningful clinical subgroup. Methods: Neuropsychological assessment, structural MRI, and genetic testing for APOE4 were administered to one hundred and twenty-five older adults over the age of 65 from the CIMAQ cohort: 66 SCD, 29 individuals with mild cognitive impairment (MCI), and 30 cognitively intact controls (CTRLS). Multiple regression models were first used to identify which factor (hippocampal volume, APOE4 allele, or cognitive reserve) best predicted inter-individual differences in a Face-name association memory task within the SCD group. Results: Hippocampal volume was found to be the only and best predictor of memory performance. We then compared the demographic, clinical and cognitive characteristics of two SCD subgroups, one with small hippocampal volume (SCD\/SH) and another with normal hippocampal volume (SCD\/NH), with MCI and CTRLS. SCD\/SH were comparable to MCI on neuropsychological tasks evaluating memory (i.e., test of delayed word recall), whereas SCD\/NH were comparable to CTRLS. Conclusion: Thus, using hippocampal volume allows identification of an SCD subgroup with a cognitive profile consistent with a higher risk of conversion to AD.<\/jats:p>","DOI":"10.3233\/jad-230131","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T06:56:39Z","timestamp":1687589799000},"page":"1047-1056","source":"Crossref","is-referenced-by-count":8,"title":["Hippocampal Volume and Episodic Associative Memory Identify Memory Risk in Subjective Cognitive Decline Individuals in the CIMA-Q Cohort, Regardless of Cognitive Reserve Level and APOE4 Status"],"prefix":"10.1177","volume":"94","author":[{"given":"Marie","family":"Caillaud","sequence":"first","affiliation":[{"name":"Research Centre, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Consortium for the Early Identification of Alzheimer\u2019s Disease-Quebec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Maltezos","sequence":"additional","affiliation":[{"name":"Research Centre, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Hudon","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"VITAM Research Centre, Centre Int\u00e9gr\u00e9 Universitaire en Sant\u00e9 et Services Sociaux de la Capitale-Nationale, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Psychology, Universit\u00e9 de Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mellah","sequence":"additional","affiliation":[{"name":"Research Centre, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Belleville","sequence":"additional","affiliation":[{"name":"Research Centre, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230131_ref1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive 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