{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:15:17Z","timestamp":1788585317059,"version":"build-2803163510"},"reference-count":56,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,9,12]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Apathy and depression are two early behavioral symptoms in Alzheimer's disease (AD) and related disorders that often occur prior to the onset of cognitive decline and memory disturbances. Both have been associated with an increased risk of conversion to dementia, with a distinct neuropathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The assessment of the trajectories of apathy and depression and their independent impact on dementia conversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Apathy and Depression were measured using the Neuropsychiatric Inventory for caregiver (NPI) and clinician (NPI-C), among the nondemented individuals reporting subjective cognitive decline (SCD) at baseline. They were followed up over a 60-month period. Some converted to dementia, according to the methodology carried out by the French Memento Cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among individuals with SCD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 323), the levels of apathy and depression were low and did not evolve significantly over the 60-month period, despite a trend in apathy increasing as of month 24. Regarding SCD individuals who converted to dementia within the 60-month period (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 27), the prevalence of depression remained globally steady, while the levels of apathy increased over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Apathy and depression have different trajectories among individuals with SCD and apathy alone is more likelypared to depressionbe associated with conversion to dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230162","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:41:10Z","timestamp":1691152870000},"page":"415-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Different Trajectories of Apathy and Depression Among Subjective Cognitive Impairment Individuals with or without Conversion to Dementia: Results from the Memento Cohort in France"],"prefix":"10.1177","volume":"95","author":[{"given":"Anamaria","family":"Bogdan","sequence":"first","affiliation":[{"name":"Cote d'Azur University","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Fabre","sequence":"additional","affiliation":[{"name":"Nice University Hospital","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Desmidt","sequence":"additional","affiliation":[{"name":"Tours University 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