{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:55:13Z","timestamp":1779224113586,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Background: Accessible measurements for the early detection of mild cognitive impairment (MCI) due to Alzheimer\u2019s disease (AD) are urgently needed to address the increasing prevalence of AD. Objective: To determine the benefits of a composite MemTrax Memory Test and AD-related blood biomarker assessment for the early detection of MCI-AD in non-specialty clinics. Methods: The MemTrax Memory Test and Montreal Cognitive Assessment were administered to 99 healthy seniors with normal cognitive function and 101 patients with MCI-AD; clinical manifestation and peripheral blood samples were collected. We evaluated correlations between the MemTrax Memory Test and blood biomarkers using Spearman\u2019s rank correlation analyses and then built discrimination models using various machine learning approaches that combined the MemTrax Memory Test and blood biomarker results. The models\u2019 performances were assessed according to the areas under the receiver operating characteristic curve. Results: The MemTrax Memory Test and Montreal Cognitive Assessment areas under the curve for differentiating patients with MCI-AD from the healthy controls were similar. The MemTrax Memory Test strongly correlated with phosphorylated tau 181 and amyloid-\u03b242\/40. The area under the curve for the best composite MemTrax Memory Test and blood biomarker model was 0.975 (95% confidence interval: 0.950\u20130.999). Conclusion: Combining MemTrax Memory Test and blood biomarker results is a promising new technique for the early detection of MCI-AD.<\/jats:p>","DOI":"10.3233\/jad-230182","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T06:51:24Z","timestamp":1687589484000},"page":"1093-1103","source":"Crossref","is-referenced-by-count":7,"title":["Early Diagnosis of Mild Cognitive Impairment due to Alzheimer\u2019s Disease Using a Composite of MemTrax and Blood Biomarkers"],"prefix":"10.1177","volume":"94","author":[{"given":"Weineng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cha","family":"Lin","sequence":"additional","affiliation":[{"name":"Neurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chian","family":"Chen","sequence":"additional","affiliation":[{"name":"The School of Intelligent Systems Engineering, Sun Yat-sen University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Alzheimer\u2019s Research, Washington Institute of Clinical Research, Vienna, VA, USA"},{"name":"AstraNeura, Co., Ltd., Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis B.","family":"Ashford","sequence":"additional","affiliation":[{"name":"MemTrax, LLC., Redwood City, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Moore Threads Co., Ltd., Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Wesson","family":"Ashford","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Sciences, Stanford University, War Related Illness & Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Ling","family":"Fu","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Hospital, Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230182_ref1","doi-asserted-by":"crossref","unstructured":"(2021) 2021 Alzheimer\u2019s disease facts and figures. 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