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To date, no one model exists with amyloidopathy in a BALB\/c strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To generate and characterize the C.B6\/J-\n                      <jats:italic toggle=\"yes\">\n                        APP\n                        <jats:sub>\n                          <jats:italic toggle=\"yes\">swe<\/jats:italic>\n                        <\/jats:sub>\n                      <\/jats:italic>\n                      mouse, a model of AD with a mutated human gene for the amyloid-\u03b2 protein precursor (A\u03b2PP) inserted in a BALB\/c background.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We analyzed five groups at different ages (3, 6, 9, 12, and 16\u201318 months) of C.B6\/J-\n                      <jats:italic toggle=\"yes\">\n                        APP\n                        <jats:sub>\n                          <jats:italic toggle=\"yes\">swe<\/jats:italic>\n                        <\/jats:sub>\n                      <\/jats:italic>\n                      and wild-type mice (50% males and 50% females) for the main hallmarks of AD by western blotting, amyloid-\u03b2 (A\u03b2) ELISA, immunocytochemistry, electrophysiology, and behavioral tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The C.B6\/J-\n                      <jats:italic toggle=\"yes\">\n                        APP\n                        <jats:sub>\n                          <jats:italic toggle=\"yes\">swe<\/jats:italic>\n                        <\/jats:sub>\n                      <\/jats:italic>\n                      mouse displays early A\u03b2PP and A\u03b2 production, late amyloid plaques formation, high level of Tau phosphorylation, synaptic deficits (reduced density and functional impairment due to a reduced post-synaptic responsiveness), neurodegeneration caused by apoptosis and necroptosis\/necrosis, microgliosis, astrocytic abnormalities, and sex-related differences in explorative behavior, anxiety-like behavior, and spatial long-term and working memories. Social housing is feasible despite the intra-cage aggressiveness of male animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      C.B6\/J-\n                      <jats:italic toggle=\"yes\">\n                        APP\n                        <jats:sub>\n                          <jats:italic toggle=\"yes\">swe<\/jats:italic>\n                        <\/jats:sub>\n                      <\/jats:italic>\n                      mice develop most of the distinctive features of AD and is a suitable model for the study of brain atrophy mechanisms and of the differences between males and females in the onset of cognitive\/non-cognitive deficits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230195","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:40:24Z","timestamp":1683898824000},"page":"1485-1508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Generation and Characterization of the First Murine Model of Alzheimer\u2019s Disease with Mutated A\u03b2PP Inserted in a BALB\/c Background (C.B6\/J-APP\n                    <sub>\n                      <i>swe<\/i>\n                    <\/sub>\n                    )"],"prefix":"10.1177","volume":"93","author":[{"given":"Marta","family":"Balietti","sequence":"first","affiliation":[{"name":"Center for Neurobiology of Aging","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Casoli","sequence":"additional","affiliation":[{"name":"Center for Neurobiology of Aging","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Giorgetti","sequence":"additional","affiliation":[{"name":"Center for Neurobiology of Aging","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Colangeli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Solazzi","sequence":"additional","affiliation":[{"name":"Center for Neurobiology of Aging","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Conti","sequence":"additional","affiliation":[{"name":"Center for Neurobiology of Aging","place":["Italy"]},{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]},{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020286"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158208"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12209"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104541"},{"key":"e_1_3_6_6_2","unstructured":"Alzheimer Research Forum Databases Research models: https:\/\/www.alzforum.org\/research-models Last updated February 6 2023 Accessed on February 10 2023."},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2020_141"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170505101426"},{"key":"e_1_3_6_9_2","unstructured":"Mouse genome informatics Inbred strains of mice BALB\/c: http:\/\/www.informatics.jax.org\/inbred_strains\/mouse\/docs\/BALB.shtml Last updated January 31 2023 Accessed on February 10 2023."},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.06.025"},{"key":"e_1_3_6_11_2","unstructured":"Mouse genome informatics Guidelines for Nomenclature of Mouse and Rat Strains: http:\/\/www.informatics.jax.org\/mgihome\/nomen\/strains.shtml Last updated January 31 2023 Accessed on February 10 2023."},{"key":"e_1_3_6_12_2","unstructured":"National Competent Authorities for the implementation of Directive 2010\/63\/EU on the protection of animals used for scientific purposes - 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