{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:30:12Z","timestamp":1780990212529,"version":"3.54.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,8,29]]},"abstract":"\n Background:<\/jats:title>\n Cognitive impairment (CI) is highly prevalent in patients undergoing hemodialysis. Whether fluid overload with malnutrition as assessed by the ratio of extracellular water to intracellular water (ECW\/ICW) is associated with CI in patients on maintenance hemodialysis (MHD) has yet to be studied.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study aimed to investigate the association between ECW\/ICW and CI in patients with MHD.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We conducted a multicenter, cross-sectional study that enrolled 3,025 adult patients with MHD. Cognitive function was assessed through the Mini-Mental State Examination. The ECW\/ICW was derived from a portable body composition monitor and analyzed by quartiles.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 23.04% of participants had CI in our study. The prevalence of CI tended to increase as the quartiles of the ECW\/ICW ratio increased. Unadjusted analysis showed that participants in quartile 4 were 3.02 times more likely to have a CI compared to those in quartile 1. After adjusting for age, sex, education, smoking status, body mass index, dialysis vintage, history of hypertension, and history of stroke, the adjusted OR (95% CI) for the highest quartile of ECW\/ICW ratio was 1.36 (1.01, 1.83) for CI compared with the lowest quartile. Interestingly, the association between ECW\/ICW ratio and CI persisted across all subgroups stratified by age, gender, history of diabetes, and stroke. (p for interaction\u200a>\u200a0.05 for all).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n An increased ECW\/ICW ratio is associated with higher odds of cognitive impairment in patients undergoing hemodialysis.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jad-230196","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:22:56Z","timestamp":1690287776000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Higher Whole-Body Extracellular to Intracellular Water Ratio Is Associated with Increased Odds of Cognitive Impairment in Hemodialysis Patients"],"prefix":"10.1177","volume":"95","author":[{"given":"Chaomin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Nephrology, NHC Key Laboratory of Pulmonary Immune-related Diseases, Renal Division, Guizhou Provincial People\u2019s Hospital, Guiyang, China"},{"name":"Medical College, Gui Zhou University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Research Laboratory Center, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology, NHC Key Laboratory of Pulmonary Immune-related Diseases, Renal Division, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, NHC Key Laboratory of Pulmonary Immune-related Diseases, Renal Division, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, NHC Key Laboratory of Pulmonary Immune-related Diseases, Renal Division, Guizhou Provincial People\u2019s Hospital, Guiyang, China"},{"name":"Medical College, Gui Zhou University, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-021-01170-3"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07550-4"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14976"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.828162"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112659"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111175"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-015-0658-x"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007776"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69482-1"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183281"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3390\/nu15051274"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13104"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040431"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022004389"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113616"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12890"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.10.012"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1982.243.3.R271"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajkd.2003.07.002"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886473"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000043"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.03.017"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.008"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-021-1603-9"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0777-1"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2018.06.005"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-230196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:18Z","timestamp":1777370898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-230196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,8,29]]}},"alternative-id":["10.3233\/JAD-230196"],"URL":"https:\/\/doi.org\/10.3233\/jad-230196","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}