{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:41Z","timestamp":1790957681075,"version":"4.1.0"},"reference-count":290,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,10,10]]},"abstract":"<jats:p>Vitamin D is a secosteroid hormone exerting neurosteroid-like properties. Its well-known nuclear hormone receptor, and recently proposed as a mitochondrial transcription factor, vitamin D receptor, acts for its primary functions. The second receptor is an endoplasmic reticulum protein, protein disulfide isomerase A3 (PDIA3), suggested to act as a rapid response. Vitamin D has effects on various systems, particularly through calcium metabolism. Among them, the nervous system has an important place in the context of our subject. Recent studies have shown that vitamin D and its receptors have numerous effects on the nervous system. Neurodegeneration is a long-term process. Throughout a human life span, so is vitamin D deficiency. Our previous studies and others have suggested that the out-come of long-term vitamin D deficiency (hypovitaminosis D or inefficient utilization of vitamin D), may lead neurons to be vulnerable to aging and neurodegeneration. We suggest that keeping vitamin D levels at adequate levels at all stages of life, considering new approaches such as agonists that can activate vitamin D receptors, and utilizing other derivatives produced in the synthesis process with UVB are crucial when considering vitamin D-based intervention studies. Given most aspects of vitamin D, this review outlines how vitamin D and its receptors work and are involved in neurodegeneration, emphasizing Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3233\/jad-230214","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:26:42Z","timestamp":1693567602000},"page":"1273-1299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin D, a Secosteroid Hormone and Its Multifunctional Receptor, Vitamin D Receptor, in Alzheimer\u2019s Type Neurodegeneration"],"prefix":"10.1177","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-2111","authenticated-orcid":false,"given":"Duygu","family":"Gezen-Ak","sequence":"first","affiliation":[{"name":"Institute of Neurological Sciences, Istanbul University-Cerrahpasa","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-6674","authenticated-orcid":false,"given":"Erdinc","family":"Dursun","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, Istanbul University-Cerrahpasa","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2015"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2009.04.002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00547-1"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00195-J"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-016-2647-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-016-8415-9"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00245"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131970"},{"key":"e_1_3_4_10_2","first-page":"265","article-title":"Vitamin D and cognition in older adults: International consensus guidelines","volume":"14","author":"Annweiler C","year":"2016","unstructured":"AnnweilerC, DursunE, FeronF, Gezen-AkD, KalueffAV, LittlejohnsT, LlewellynD, MilletP, ScottT, TuckerKL, YilmazerS, BeauchetO (2016) Vitamin D and cognition in older adults: International consensus guidelines. Geriatr Psychol Neuropsychiatr Vieil 14, 265\u2013273.","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12279"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0086-5"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0087-4"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00512"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.12.007"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-679"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01202.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050360"},{"key":"e_1_3_4_19_2","first-page":"265","article-title":"DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor","volume":"8","author":"Freedman LP","year":"1994","unstructured":"FreedmanLP, ArceV, Perez FernandezR (1994) DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor. Mol Endocrinol 8, 265\u2013273.","journal-title":"Mol Endocrinol"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600710203"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.4.694"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.818"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.01.013"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.12.009"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107932"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010087"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0722-7"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.02.002"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22645"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1268-6"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01680.x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.11.003"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200578R"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.11.010"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009907"},{"key":"e_1_3_4_37_2","first-page":"179","article-title":"Cancer, sunlight and vitamin D","volume":"1","author":"Holick MF","year":"2014","unstructured":"HolickMF (2014) Cancer, sunlight and vitamin D. J Clin Transl Endocrinol 1, 179\u2013186.","journal-title":"J Clin Transl Endocrinol"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.4161\/derm.24494"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2015.1039866"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1086\/323473"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-021-00602-5"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00683.x"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg072"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.699546"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00167"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10338"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.04.132"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.1.138-142.1999"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.07s211"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3124"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8369"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00022727"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00303-3"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02450-7"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130416"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017553"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101377"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.07.001"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.03.007"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054546"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.035"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00111"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181beecd3"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334944"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03675.x"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982668"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.10.1348"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988708327888"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.173"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1159\/000134382"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000240986.74642.7c"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300310"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01030-2"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988716640373"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2016.11.007"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-018-8498-6"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350319"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101986"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112459225"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05020-11"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.05.023"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150943"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0087-2"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-110560"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121735"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-244"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.4274\/npa.y7089"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.4274\/npa.y7076"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1080"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.31989\/ffhd.v1i12.107"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-8-20"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20670"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-4-1433"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.03.010"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.01.008"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0536-9"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9048-4"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.11.010"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.161"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122005"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.01.015"},{"key":"e_1_3_4_102_2","first-page":"32","article-title":"Vitamin D status as an international issue: National surveys and the problem of standardization","volume":"243","author":"Sempos CT","year":"2012","unstructured":"SemposCT, VesperHW, PhinneyKW, ThienpontLM, CoatesPM, VitaminDSP (2012) Vitamin D status as an international issue: National surveys and the problem of standardization. Scand J Clin Lab Invest Suppl 243, 32\u201340.","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120873"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.227728"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103689"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5769-y"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9326rev"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000755"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003906"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192013086"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170407"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181beecb7"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130452"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-121432"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1500-6"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016804"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1436639"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1765"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12404"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1177\/08919887231163292"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030639"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.204"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2011.01.004"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12919-018-0102-4"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010014"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082237"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55090541"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130719"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-01064-8"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095202"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-63260-5_6"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-014-9501-z"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2589276"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191247"},{"key":"e_1_3_4_136_2","first-page":"86","article-title":"The effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin and insulin resistance of type 2 diabetes mellitus patients: A pilot study","volume":"19","author":"Gharekhani A","year":"2020","unstructured":"GharekhaniA, NajafipourF, BaradaranH, TagharrobiP, RezaeeH (2020) The effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin and insulin resistance of type 2 diabetes mellitus patients: A pilot study. Iran J Pharm Res 19, 86\u201394.","journal-title":"Iran J Pharm Res"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114718"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab168"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.31"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.328"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00373"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114047"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0432"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071684"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871527322666230526164421"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16909"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.11"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0619-x"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110149"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.11.020"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200926"},{"key":"e_1_3_4_153_2","first-page":"1347","article-title":"Effects of vitamin D supplementation on cognitive function and blood Abeta-related biomarkers in older adults with Alzheimer\u2019s disease: A randomised, double-blind, placebo-controlled trial","volume":"90","author":"Jia J","year":"2019","unstructured":"JiaJ, HuJ, HuoX, MiaoR, ZhangY, MaF (2019) Effects of vitamin D supplementation on cognitive function and blood Abeta-related biomarkers in older adults with Alzheimer\u2019s disease: A randomised, double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry 90, 1347\u20131352.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e31826df647"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00021-X"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_4_157_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220407"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1746"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009040451"},{"key":"e_1_3_4_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.08.006"},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69128-2"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00181"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.08.018"},{"key":"e_1_3_4_164_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1254-4"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.67"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16434"},{"key":"e_1_3_4_167_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210697200"},{"key":"e_1_3_4_168_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.22.9985-9995.2005"},{"key":"e_1_3_4_169_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304886200"},{"key":"e_1_3_4_170_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107920.110"},{"key":"e_1_3_4_171_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096105"},{"key":"e_1_3_4_172_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1109"},{"key":"e_1_3_4_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.028"},{"key":"e_1_3_4_174_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.12.3215"},{"key":"e_1_3_4_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.07.020"},{"key":"e_1_3_4_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.07.023"},{"key":"e_1_3_4_177_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00315-x"},{"key":"e_1_3_4_178_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-6-6"},{"key":"e_1_3_4_179_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188605"},{"key":"e_1_3_4_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.04.090"},{"key":"e_1_3_4_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.062"},{"key":"e_1_3_4_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.06.009"},{"key":"e_1_3_4_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2015.04.005"},{"key":"e_1_3_4_184_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24033005"},{"key":"e_1_3_4_185_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105531"},{"key":"e_1_3_4_186_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01338-3"},{"key":"e_1_3_4_187_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00248"},{"key":"e_1_3_4_188_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000038"},{"key":"e_1_3_4_189_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1352-11.2012"},{"key":"e_1_3_4_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02215-4"},{"key":"e_1_3_4_191_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00004"},{"key":"e_1_3_4_192_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00959"},{"key":"e_1_3_4_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.004"},{"key":"e_1_3_4_194_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1459706"},{"key":"e_1_3_4_195_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22330"},{"key":"e_1_3_4_196_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01561"},{"key":"e_1_3_4_197_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16014"},{"key":"e_1_3_4_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87061-w"},{"key":"e_1_3_4_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.10.016"},{"key":"e_1_3_4_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01139-5"},{"key":"e_1_3_4_201_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100940"},{"key":"e_1_3_4_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90032-7"},{"key":"e_1_3_4_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02130-9"},{"key":"e_1_3_4_204_2","doi-asserted-by":"publisher","DOI":"10.1038\/1243"},{"key":"e_1_3_4_205_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1905"},{"key":"e_1_3_4_206_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.10026"},{"key":"e_1_3_4_207_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.275"},{"key":"e_1_3_4_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.057"},{"key":"e_1_3_4_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.12.008"},{"key":"e_1_3_4_210_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.017137"},{"key":"e_1_3_4_211_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.244962"},{"key":"e_1_3_4_212_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.228.189"},{"key":"e_1_3_4_213_2","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2020.1820502"},{"key":"e_1_3_4_214_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091243"},{"key":"e_1_3_4_215_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003430"},{"key":"e_1_3_4_216_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00098.2001"},{"key":"e_1_3_4_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135598"},{"key":"e_1_3_4_218_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111203"},{"key":"e_1_3_4_219_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122764"},{"key":"e_1_3_4_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.09.008"},{"key":"e_1_3_4_221_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.013227"},{"key":"e_1_3_4_222_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.275re4"},{"key":"e_1_3_4_223_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0839-1"},{"key":"e_1_3_4_224_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160133"},{"key":"e_1_3_4_225_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00572"},{"key":"e_1_3_4_226_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228538"},{"key":"e_1_3_4_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.11.012"},{"key":"e_1_3_4_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.11.014"},{"key":"e_1_3_4_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.08.005"},{"key":"e_1_3_4_230_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-16"},{"key":"e_1_3_4_231_2","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:2:147"},{"key":"e_1_3_4_232_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.029"},{"key":"e_1_3_4_233_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191164"},{"key":"e_1_3_4_234_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600392"},{"key":"e_1_3_4_235_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-019-04104-x"},{"key":"e_1_3_4_236_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.684399"},{"key":"e_1_3_4_237_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2018.09.002"},{"key":"e_1_3_4_238_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002383"},{"key":"e_1_3_4_239_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008670"},{"key":"e_1_3_4_240_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054716"},{"key":"e_1_3_4_241_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061672"},{"key":"e_1_3_4_242_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109322"},{"key":"e_1_3_4_243_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10191"},{"key":"e_1_3_4_244_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1283"},{"key":"e_1_3_4_245_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-03-0196"},{"key":"e_1_3_4_246_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3066-7"},{"key":"e_1_3_4_247_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01122"},{"key":"e_1_3_4_248_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2637fje"},{"key":"e_1_3_4_249_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160415"},{"key":"e_1_3_4_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.06.017"},{"key":"e_1_3_4_251_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.06.004"},{"key":"e_1_3_4_252_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.021"},{"key":"e_1_3_4_253_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095"},{"key":"e_1_3_4_254_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22083"},{"key":"e_1_3_4_255_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21361"},{"key":"e_1_3_4_256_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05770"},{"key":"e_1_3_4_257_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027680"},{"key":"e_1_3_4_258_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm195"},{"key":"e_1_3_4_259_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24459"},{"key":"e_1_3_4_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.043"},{"key":"e_1_3_4_261_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.08.009"},{"key":"e_1_3_4_262_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.084129.108"},{"key":"e_1_3_4_263_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-018-1223-y"},{"key":"e_1_3_4_264_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.056986"},{"key":"e_1_3_4_265_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1846"},{"key":"e_1_3_4_266_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000215770.79281.e4"},{"key":"e_1_3_4_267_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.10.014"},{"key":"e_1_3_4_268_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00637-w"},{"key":"e_1_3_4_269_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.016"},{"key":"e_1_3_4_270_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_3_4_271_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800503"},{"key":"e_1_3_4_272_2","first-page":"e31710","article-title":"The efficacy of vitamin D supplementation in patients with Alzheimer\u2019s disease in preventing cognitive decline: A systematic review","volume":"14","author":"Chakkera M","year":"2022","unstructured":"ChakkeraM, RaviN, RamarajuR, VatsA, NairAR, BandhuAK, KoiralaD, PallapothuMR, Quintana MarinezMG, KhanS (2022) The efficacy of vitamin D supplementation in patients with Alzheimer\u2019s disease in preventing cognitive decline: A systematic review. Cureus 14, e31710.","journal-title":"Cureus"},{"key":"e_1_3_4_273_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104893"},{"key":"e_1_3_4_274_2","doi-asserted-by":"publisher","DOI":"10.1159\/000510400"},{"key":"e_1_3_4_275_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076362"},{"key":"e_1_3_4_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.014"},{"key":"e_1_3_4_277_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.01.041"},{"key":"e_1_3_4_278_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081824"},{"key":"e_1_3_4_279_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1665854"},{"key":"e_1_3_4_280_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13670"},{"key":"e_1_3_4_281_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00504-2"},{"key":"e_1_3_4_282_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1787624"},{"key":"e_1_3_4_283_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00529-7"},{"key":"e_1_3_4_284_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.003"},{"key":"e_1_3_4_285_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2020.108586"},{"key":"e_1_3_4_286_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105260"},{"key":"e_1_3_4_287_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0372-x"},{"key":"e_1_3_4_288_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00442-3"},{"key":"e_1_3_4_289_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2015.10.011"},{"key":"e_1_3_4_290_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1375858"},{"key":"e_1_3_4_291_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14147"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-230214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:30Z","timestamp":1777370910000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-230214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":290,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,10]]}},"alternative-id":["10.3233\/JAD-230214"],"URL":"https:\/\/doi.org\/10.3233\/jad-230214","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}