{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:51:17Z","timestamp":1792641077912,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD), the most common cause of dementia, is a neurodegenerative disease resulting from extracellular and intracellular deposits of amyloid-\u03b2 (A\u03b2) and neurofibrillary tangles in the brain. Although many clinical studies evaluating pharmacological approaches have been conducted, most have shown disappointing results; thus, innovative strategies other than drugs have been actively attempted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to explore low-dose radiation therapy (LDRT) for the treatment of patients with AD based on preclinical evidence, case reports, and a small pilot trial in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study is a phase II, multicenter, prospective, single-blinded, randomized controlled trial that will evaluate the efficacy and safety of LDRT to the whole brain using a linear accelerator in patients with mild AD. Sixty participants will be randomly assigned to three groups: experimental I (24 cGy\/6 fractions), experimental II (300 cGy\/6 fractions), or sham RT group (0 cGy\/6 fractions). During LDRT and follow-up visits after LDRT, possible adverse events will be assessed by the physician\u2019s interview and neurological examinations. Furthermore, the effectiveness of LDRT will be measured using neurocognitive function tests and imaging tools at 6 and 12 months after LDRT. We will also monitor the alterations in cytokines, A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      ratio, and tau levels in plasma. Our primary endpoint is the change in cognitive function test scores estimated by the Alzheimer\u2019s Disease Assessment Scale-Korea compared to baseline after 6 months of LDRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study is registered at ClinicalTrials.gov [NCT05635968] and is currently recruiting patients. This study will provide evidence that LDRT is a new treatment strategy for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230241","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:50:16Z","timestamp":1692960616000},"page":"1263-1272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Efficacy and Safety Using Low Dose Radiation Therapy with Alzheimer\u2019s Disease: A Protocol for Multicenter Phase II Clinical Trial"],"prefix":"10.1177","volume":"95","author":[{"given":"Dong-Yun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Kyunghee University Hospital at Gangdong, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Soonchunhyang University Seoul Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chungbuk National University Hospital, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chungbuk National University Hospital, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Hyuck","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hee","family":"Hong","sequence":"additional","affiliation":[{"name":"Radiation Health Research Institute, Korea Hydro & Nuclear Power Co Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Radiation Health Research Institute, Korea Hydro & Nuclear Power Co Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Jun","family":"Cho","sequence":"additional","affiliation":[{"name":"Radiation Health Research Institute, Korea Hydro & Nuclear Power Co Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Young","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyunghee University Hospital at Gangdong, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chungbuk National University Hospital, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun You","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Jong","family":"Oh","sequence":"additional","affiliation":[{"name":"Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon Kuu","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kyunghee University Hospital at Gangdong, Seoul, 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