{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:11:58Z","timestamp":1777396318222,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Background: Little is known regarding the differential effects of the apolipoprotein E (APOE) \u025b4 on the regional topography of amyloid and tau in patients with both early-onset (EOAD) and late-onset Alzheimer\u2019s disease (LOAD). Objective: To compare the distribution and association of tau, amyloid, and cortical thickness among groups classified by the presence of APOE \u025b4 allele and onset age. Methods: A total of 165 participants including 54 EOAD patients (29 \u025b4-; 25 \u025b4+), 45 LOAD patients (21 \u025b4-; 24 \u025b4+), and 66 age-matched controls underwent 3T MRI, 18F-THK5351 (THK) and 18F-flutemetamol (FLUTE) PET scans, APOE genotyping, and neuropsychological tests. Data for voxel-wise and standardized uptake values from PET scans were analyzed in the context of APOE and age at onset. Results: EOAD \u025b4- patients showed greater THK retention in the association cortices, whereas their EOAD \u025b4+ counterparts had more retention in medial temporal areas. THK topography of LOAD \u025b4+ was similar to EOAD \u025b4\u200a+\u200a. THK correlated positively with FLUTE and conversely with mean cortical thickness, being lowest in EOAD \u025b4-, highest in LOAD \u025b4-, and modest in \u025b4+ groups. Even in the APOE \u025b4+ groups, THK tended to correlate with FLUTE and mean cortical thickness in the inferior parietal region in EOAD and in the medial temporal region in LOAD. LOAD \u025b4- manifested with prevalent small vessel disease markers and the lowest correlation between THK retention and cognition. Conclusion: Our observations suggest the differential effects of the APOE \u025b4 on the relationship between tau and amyloid in EOAD and LOAD.<\/jats:p>","DOI":"10.3233\/jad-230339","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T11:54:30Z","timestamp":1687866870000},"page":"1233-1246","source":"Crossref","is-referenced-by-count":2,"title":["Effects of the APOE \u025b4 Allele on the Relationship Between Tau and Amyloid-\u03b2 in Early- and Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"94","author":[{"given":"Jae Myeong","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hyeon","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Korea University, Seoul, Republic of Korea"},{"name":"Bio Medical Research Center, Bio Medical & Health Division, Korea Testing Laboratory, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Ram","family":"Kim","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongho","family":"Seo","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeun","family":"Seo","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, College of Medicine, Gachon University, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul, Republic of Korea; Happymind Clinic, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Kyoung","family":"Seong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Korea University, Seoul, Republic of Korea"},{"name":"Department of Artificial Intelligence, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea"},{"name":"Department of Health Science and Technology, GAIHST, Gachon University, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230339_ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.ne.19.030196.000413","article-title":"Apolipoprotein E and Alzheimer\u2019s disease","volume":"19","author":"Strittmatter","year":"1996","journal-title":"Annu Rev Neurosci"},{"key":"10.3233\/JAD-230339_ref2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer\u2019s disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"10.3233\/JAD-230339_ref3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.01.056","article-title":"A quarter century of APOE and Alzheimer\u2019s disease: Progress to date and the path forward","volume":"101","author":"Belloy","year":"2019","journal-title":"Neuron"},{"key":"10.3233\/JAD-230339_ref4","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1523\/JNEUROSCI.2994-18.2019","article-title":"Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer\u2019s disease risk","volume":"39","author":"Huang","year":"2019","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-230339_ref5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.25455","article-title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in Alzheimer disease","volume":"85","author":"Wadhwani","year":"2019","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-230339_ref6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer\u2019s disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.3233\/JAD-230339_ref7","unstructured":"Bertram L , McQueen M , Mullin K , Blacker D , Tanzi R (2005) The AlzGene Database. 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