{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:17:49Z","timestamp":1790302669576,"version":"4.1.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Background: Comprehensive treatment of Alzheimer\u2019s disease and related dementias (ADRD) requires not only pharmacologic treatment but also management of existing medical conditions and lifestyle modifications including diet, cognitive training, and exercise. Personalized, multimodal therapies are needed to best prevent and treat Alzheimer\u2019s disease (AD). Objective: The Coaching for Cognition in Alzheimer\u2019s (COCOA) trial was a prospective randomized controlled trial to test the hypothesis that a remotely coached multimodal lifestyle intervention would improve early-stage AD. Methods: Participants with early-stage AD were randomized into two arms. Arm 1 (N\u200a=\u200a24) received standard of care. Arm 2 (N\u200a=\u200a31) additionally received telephonic personalized coaching for multiple lifestyle interventions. The primary outcome was a test of the hypothesis that the Memory Performance Index (MPI) change over time would be better in the intervention arm than in the control arm. The Functional Assessment Staging Test was assessed for a secondary outcome. COCOA collected psychometric, clinical, lifestyle, genomic, proteomic, metabolomic, and microbiome data at multiple timepoints (dynamic dense data) across two years for each participant. Results: The intervention arm ameliorated 2.1 [1.0] MPI points (mean [SD], p\u200a=\u200a0.016) compared to the control over the two-year intervention. No important adverse events or side effects were observed. Conclusion: Multimodal lifestyle interventions are effective for ameliorating cognitive decline and have a larger effect size than pharmacological interventions. Dietary changes and exercise are likely to be beneficial components of multimodal interventions in many individuals. Remote coaching is an effective intervention for early stage ADRD. Remote interventions were effective during the COVID pandemic.<\/jats:p>","DOI":"10.3233\/jad-230403","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:14:42Z","timestamp":1696940082000},"page":"591-607","source":"Crossref","is-referenced-by-count":18,"title":["A Remotely Coached Multimodal Lifestyle Intervention for Alzheimer\u2019s Disease Ameliorates Functional and Cognitive Outcomes"],"prefix":"10.1177","volume":"96","author":[{"given":"Jared C.","family":"Roach","sequence":"first","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"COCOA Consortium: AttharaMouna BaloniPriyanka DillLauren EdensLance E. FischerDan FortierDennis FridmanDeborah FunkCory C. GlusmanGw\u00eanlyn HaraJunko HoodLeroy JadeKathleen LovejoyJennifer C. MagisAndrew MarkewychDaria R. PriceNathan RapozoMolly K. RoachJared C. ShankleWilliam R.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly K.","family":"Rapozo","sequence":"additional","affiliation":[{"name":"Providence St. Joseph Health, Renton, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Hara","sequence":"additional","affiliation":[{"name":"Pickup Family Neurosciences Institute, Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gw\u00eanlyn","family":"Glusman","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lovejoy","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Shankle","sequence":"additional","affiliation":[{"name":"Pickup Family Neurosciences Institute, Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA"},{"name":"Department of Cognitive Sciences, University of California, Irvine, CA, USA"},{"name":"Shankle Clinic, Newport Beach, CA, USA"},{"name":"EMBIC Corporation, Newport Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Hood","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230403_ref1","doi-asserted-by":"crossref","first-page":"e12297","DOI":"10.1002\/trc2.12297","article-title":"Dense data enables twenty-first century clinical trials","volume":"8","author":"Roach","year":"2022","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3233\/JAD-230403_ref2","first-page":"243","article-title":"Optimal management of Alzheimer\u2019s disease patients: Clinical guidelines and family advice","volume":"6","author":"Haberstroh","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.3233\/JAD-230403_ref3","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/brain\/awz384","article-title":"A multiomics approach to heterogeneity in Alzheimer\u2019s disease: Focused review and roadmap","volume":"143","author":"Badhwar","year":"2020","journal-title":"Brain"},{"key":"10.3233\/JAD-230403_ref4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7326\/0003-4819-109-1-41","article-title":"Brain amyloid and Alzheimer disease","volume":"109","author":"Vinters","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.3233\/JAD-230403_ref5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.3233\/JAD-230403_ref6","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.jalz.2018.08.004","article-title":"The clinical practice of risk reduction for Alzheimer\u2019s disease: A precision medicine approach","volume":"14","author":"Isaacson","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref7","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3233\/JAD-215707","article-title":"Precision medicine approach to Alzheimer\u2019s disease: Successful pilot project","volume":"88","author":"Toups","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-230403_ref8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/alz.12421","article-title":"Mediterranean and Western diet effects on Alzheimer\u2019s disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial","volume":"18","author":"Hoscheidt","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref9","doi-asserted-by":"crossref","first-page":"e072691","DOI":"10.1136\/bmj-2022-072691","article-title":"Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study","volume":"380","author":"Jia","year":"2023","journal-title":"BMJ"},{"key":"10.3233\/JAD-230403_ref10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/17461391.2022.2048894","article-title":"Implementation of multiple statistical methods to estimate variability and individual response to training","volume":"23","author":"Jacques","year":"2023","journal-title":"Eur J Sport Sci"},{"key":"10.3233\/JAD-230403_ref11","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.3233\/JAD-230403_ref12","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","article-title":"MIND diet associated with reduced incidence of Alzheimer\u2019s disease","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref13","doi-asserted-by":"crossref","first-page":"e12318","DOI":"10.1002\/trc2.12318","article-title":"The Coaching for Cognition in Alzheimer\u2019s (COCOA) trial: Study design","volume":"8","author":"Roach","year":"2022","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3233\/JAD-230403_ref14","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/alz.12492","article-title":"The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)","volume":"18","author":"Ngandu","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref15","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1038\/s41598-019-43058-0","article-title":"Genetic predisposition impacts clinical changes in a lifestyle coaching program (Supplementary Material)","volume":"9","author":"Zubair","year":"2019","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-230403_ref16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/08870449808407422","article-title":"Health promotion from the perspective of social cognitive theory","volume":"13","author":"Bandura","year":"2007","journal-title":"Psychology and Health"},{"key":"10.3233\/JAD-230403_ref17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/1049731509347850","article-title":"A meta-analysis of motivational interviewing: Twenty-five years of empirical studies","volume":"20","author":"Lundahl","year":"2010","journal-title":"Res Social Work Practice"},{"key":"10.3233\/JAD-230403_ref18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cpr.2005.07.003","article-title":"The empirical status of cognitive-behavioral therapy: A review of meta-analyses","volume":"26","author":"Butler","year":"2006","journal-title":"Clin Psychol Rev"},{"key":"10.3233\/JAD-230403_ref19","doi-asserted-by":"crossref","first-page":"P996","DOI":"10.1016\/j.jalz.2016.06.2051","article-title":"Population-based cognitive health: Learnings from the Orange County Vital Brain Aging Program","volume":"12","author":"Hara","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-230403_ref22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-150881","article-title":"Screening for mild cognitive impairment: Comparison of \u201cMCI specific\u201d screening instruments","volume":"51","author":"O\u2019Caoimh","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-230403_ref23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/gps.5016","article-title":"Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta-analysis of diagnostic accuracy studies","volume":"34","author":"Breton","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-230403_ref24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-017-0297-z","article-title":"Alzheimer\u2019s disease prevention: From risk factors to early intervention","volume":"9","author":"Crous-Bou","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-230403_ref25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2017.09.006","article-title":"Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of ine characteristics: The FINGER trial","volume":"14","author":"Rosenberg","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref26","doi-asserted-by":"crossref","first-page":"e12174","DOI":"10.1002\/dad2.12174","article-title":"Adding cognition to AT(N) models improves prediction of cognitive and functional decline","volume":"13","author":"O\u2019Shea","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.3233\/JAD-230403_ref27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br J Psychiatry"},{"key":"10.3233\/JAD-230403_ref28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-230403_ref29","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1001\/archneur.65.8.1091","article-title":"Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: A Texas Alzheimer\u2019s research consortium study","volume":"65","author":"O\u2019Bryant","year":"2008","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-230403_ref30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/ADR-190126","article-title":"Global Clinical Dementia Rating Score of 0.5 may not be an accurate criterion to identify individuals with mild cognitive impairment","volume":"3","author":"Wada-Isoe","year":"2019","journal-title":"J Alzheimers Dis Rep"},{"key":"10.3233\/JAD-230403_ref31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1212\/WNL.0b013e31820ce6a5","article-title":"Global clinical dementia rating of 0.5 in MCI masks variability related to level of function","volume":"76","author":"Chang","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-230403_ref32","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1532-5415.2000.tb05004.x","article-title":"Interrater reliability of the Clinical Dementia Rating in a multicenter trial","volume":"48","author":"Rockwood","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-230403_ref33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/WAD.0000000000000031","article-title":"The Dementia Severity Rating Scale predicts clinical dementia rating sum of boxes scores","volume":"29","author":"Moelter","year":"2015","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-230403_ref34","first-page":"448","article-title":"The Alzheimer\u2019s disease assessment scale: An instrument for assessing treatment efficacy","volume":"19","author":"Mohs","year":"1983","journal-title":"Psychopharmacol Bull"},{"key":"10.3233\/JAD-230403_ref35","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jalz.2011.01.005","article-title":"Suitability of the Clinical Dementia Rating-Sum of Boxes as a single primary endpoint for Alzheimer\u2019s disease trials","volume":"7","author":"Coley","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jalz.2008.11.001","article-title":"Development and validation of the Memory Performance Index: Reducing measurement error in recall tests","volume":"5","author":"Shankle","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref37","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1073\/pnas.0501157102","article-title":"Methods to improve the detection of mild cognitive impairment","volume":"102","author":"Shankle","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-230403_ref38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1533317511402316","article-title":"Comparison of the memory performance index with standard neuropsychological measures of cognition","volume":"26","author":"Rafii","year":"2011","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.3233\/JAD-230403_ref39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/JAD-2007-11309","article-title":"Detecting cognitive impairment in primary care: Performance assessment of three screening instruments","volume":"11","author":"Trenkle","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-230403_ref40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/1533317507312624","article-title":"The Japanese MCI screen for early detection of Alzheimer\u2019s disease and related disorders","volume":"23","author":"Cho","year":"2008","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.3233\/JAD-230403_ref41","first-page":"151","article-title":"Psychometric properties of the Clinical Dementia Rating \u2013Sum of Boxes and other cognitive and functional outcomes in a prodromal Alzheimer\u2019s disease population","volume":"8","author":"McDougall","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"10.3233\/JAD-230403_ref42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0163278703261198","article-title":"Sample-size requirements for comparisons of two groups on repeated observations of a binary outcome","volume":"27","author":"Leon","year":"2004","journal-title":"Eval Health Prof"},{"key":"10.3233\/JAD-230403_ref43","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2307\/2533554","article-title":"Sample size calculations for studies with correlated observations","volume":"53","author":"Liu","year":"1997","journal-title":"Biometrics"},{"key":"10.3233\/JAD-230403_ref44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s40268-014-0057-5","article-title":"Role of cognitive enhancer therapy in Alzheimer\u2019s disease with concomitant cerebral white matter disease: Findings from a long-term naturalistic study","volume":"14","author":"Ng","year":"2014","journal-title":"Drugs R D"},{"key":"10.3233\/JAD-230403_ref45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jgs.12607","article-title":"Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults","volume":"62","author":"Rebok","year":"2014","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-230403_ref46","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1093\/eurheartj\/ehab922","article-title":"Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: The FINGER trial","volume":"43","author":"Lehtisalo","year":"2022","journal-title":"Eur Heart J"},{"key":"10.3233\/JAD-230403_ref47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/1980-5764-dn-2021-0064","article-title":"Long-term studies in cognitive training for older adults: A systematic review","volume":"16","author":"da Silva","year":"2022","journal-title":"Dement Neuropsychol"},{"key":"10.3233\/JAD-230403_ref48","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.18632\/aging.202913","article-title":"Potential reversal of epigenetic age using a diet and lifestyle intervention: A pilot randomized clinical trial","volume":"13","author":"Fitzgerald","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.3233\/JAD-230403_ref49","doi-asserted-by":"crossref","first-page":"e063995","DOI":"10.1002\/alz.063995","article-title":"Frequent cognitive tests increase power for Alzheimer\u2019s disease clinical trials","volume":"18","author":"Roach","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref50","doi-asserted-by":"crossref","first-page":"e068373","DOI":"10.1002\/alz.068373","article-title":"Not sexy enough: The uphill battle faced by non-traditional treatments in the U.S. despite having the most compelling AD results to date","volume":"18","author":"Hendrix","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref51","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/EDE.0b013e31818131e7","article-title":"Why most discovered true associations are inflated","volume":"19","author":"Ioannidis","year":"2008","journal-title":"Epidemiology"},{"key":"10.3233\/JAD-230403_ref52","doi-asserted-by":"crossref","first-page":"e063092","DOI":"10.1002\/alz.063092","article-title":"A new approach for estimating and quantifying disease-modification in Alzheimer\u2019s disease clinical trials","volume":"18","author":"Raket","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref53","first-page":"30","article-title":"Dementia: A systematic approach to identifying reversible causes","volume":"41","author":"Reisberg","year":"1986","journal-title":"Geriatrics"},{"key":"10.3233\/JAD-230403_ref54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12982-015-0037-4","article-title":"Applying the Bradford Hill criteria in the 21st century: How data integration has changed causal inference in molecular epidemiology","volume":"12","author":"Fedak","year":"2015","journal-title":"Emerg Themes Epidemiol"},{"key":"10.3233\/JAD-230403_ref55","doi-asserted-by":"crossref","first-page":"2517658","DOI":"10.1155\/2019\/2517658","article-title":"Responsiveness, minimal clinically important difference, and validity of the MoCA in stroke rehabilitation","volume":"2019","author":"Wu","year":"2019","journal-title":"Occup Ther Int"},{"key":"10.3233\/JAD-230403_ref56","doi-asserted-by":"crossref","first-page":"e12191","DOI":"10.1002\/trc2.12191","article-title":"A systems-biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer\u2019s disease","volume":"7","author":"McEwen","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3233\/JAD-230403_ref57","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1185\/030079905X56565","article-title":"Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer\u2019s disease over a 2-year period","volume":"21","author":"Bullock","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"10.3233\/JAD-230403_ref58","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/alzrt201","article-title":"Pharmacological recommendations for the symptomatic treatment of dementia: The Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012","volume":"5","author":"Herrmann","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-230403_ref59","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41591-021-01369-8","article-title":"A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer\u2019s disease","volume":"27","author":"Salloway","year":"2021","journal-title":"Nat Med"},{"key":"10.3233\/JAD-230403_ref60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41582-022-00645-6","article-title":"Early-stage Alzheimer disease: Getting trial-ready","volume":"18","author":"Aisen","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-230403_ref61","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref62","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1212\/WNL.0000000000009816","article-title":"Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies","volume":"95","author":"Dhana","year":"2020","journal-title":"Neurology"},{"key":"10.3233\/JAD-230403_ref63","first-page":"18","article-title":"Case study: A precision medicine approach to multifactorial dementia and Alzheimer\u2019s disease","volume":"11","author":"Ross","year":"2021","journal-title":"J Alzheimers Dis Parkinsonism"},{"key":"10.3233\/JAD-230403_ref64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00207454.2022.2079506","article-title":"Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer\u2019s disease: A systematic review","volume":"3","author":"Kocat\u00fcrk","year":"2022","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-230403_ref65","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/alz.12123","article-title":"World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia","volume":"16","author":"Kivipelto","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref67","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jalz.2015.05.016","article-title":"Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective","volume":"11","author":"Baumgart","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230403_ref68","doi-asserted-by":"crossref","first-page":"e0270255","DOI":"10.1371\/journal.pone.0270255","article-title":"Comparing artificial intelligence and human coaching goal attainment efficacy","volume":"17","author":"Terblanche","year":"2022","journal-title":"PLoS One"},{"key":"10.3233\/JAD-230403_ref70","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00415-022-11454-8","article-title":"Effects of physical activity and exercise interventions on Alzheimer\u2019s disease: An umbrella review of existing meta-analyses","volume":"270","author":"L\u00f3pez-Ortiz","year":"2023","journal-title":"J Neurol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-230403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:40Z","timestamp":1777370920000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-230403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":68,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-230403","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]}}}