{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:45:54Z","timestamp":1780058754442,"version":"3.54.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Age-related cognitive decline is a chronic, progressive process that requires active clinical management as cognitive status changes. Computerized cognitive training (CCT) provides cognitive exercises targeting specific cognitive domains delivered by computer or tablet. Meanwhile, CCT can be used to regularly monitor the cognitive status of patients, but it is not clear whether CCT can reliably assess cognitive ability or be used to diagnose different stages of cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether CCT can accurately monitor the cognitive status of patients with cognitive impairment as well as distinguish patients with dementia from patients with mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We included 116 patients (42 dementia and 74 MCI) in final analysis. Cognitive ability was assessed by averaging the patient performance on the CCT to determine the Cognitive Index. The validity of the Cognitive Index was evaluated by its correlation with neuropsychological tests, and internal consistency was measured to assess the reliability. Additionally, we determined the diagnostic ability of the Cognitive Index to detect dementia using receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The Cognitive Index was highly correlated with the Montreal Cognitive Assessment ( r\u200a=\u200a0.812) and the Mini-Mental State Examination ( r\u200a=\u200a0.694), indicating good convergent validity, and the Cronbach\u2019s alpha coefficient was 0.936, indicating excellent internal consistency. The area under the ROC curve, sensitivity, and specificity of the Cognitive Index to diagnose dementia were 0.943, 83.3%, and 91.9%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CCT can be used to assess cognitive status and detect dementia in patients with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230416","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:18:34Z","timestamp":1695385114000},"page":"93-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of a Computerized Cognitive Training Tool to Assess Cognitive Impairment and Enable Differentiation Between Mild Cognitive Impairment and Dementia"],"prefix":"10.1177","volume":"96","author":[{"given":"Li-Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Wisdom Spirit Technology Co., Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Wisdom Spirit Technology Co., Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Wisdom Spirit Technology Co., Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Beijing Wisdom Spirit Technology Co., Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Wisdom Spirit Technology Co., Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.01.022"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13806"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180119092427"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13244"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103287"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000069"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2018-102890"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215142"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02620-6"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.022"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001756"},{"key":"ref015","first-page":"CD012279","volume":"3","author":"Gates NJ","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319868710"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12718"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.01.009"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605194103"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2805"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91867-z"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160518"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141260"},{"key":"ref024","first-page":"61","volume":"14","author":"Mahoney FI","year":"1965","journal-title":"Md State Med J"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000118082"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970715)16:13<1529::AID-SIM565>3.0.CO;2-H"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294183"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101671"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170829111942"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13277"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2014.11.004"},{"key":"ref032","first-page":"8","volume":"3","author":"Rentz DM","year":"2016","journal-title":"J Prev Alzheimers Dis"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.4236\/psych.2012.37076"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191710495"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.2196\/games.5006"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-230416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:35Z","timestamp":1777370915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-230416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,10,24]]}},"alternative-id":["10.3233\/JAD-230416"],"URL":"https:\/\/doi.org\/10.3233\/jad-230416","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}