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Since the vasculature ages in us all, dementia is our fate, sealed by the realit!ies of the circulation; it is not a disease with a cure pending. Empirically, cognitive impairment before our 7th decade is uncommon and considered early, while a diagnosis in our 11th decade is late but common in that cohort (&gt;40%). Projections from earlier ages suggest that the prevalence of dementia in people surviving into their 12th decade exceeds 80%. We address the question why so few of many interventions known to delay dementia are recognized as therapy; and we try to resolve this few-and-many paradox, identifying opportunities for better treatment, especially pre-diagnosis. The idea of dementia as a fate is resisted, we argue, because it negates the hope of a cure. But the price of that hope is lost opportunity. An approach more in line with the evidence, and more likely to limit suffering, is to understand the damage that accumulates with age in the cerebral vasculature and therefore in the brain, and which eventually gives rise to cognitive symptoms in late life, too often leading to dementia. We argue that hope should be redirected to delaying that damage and with it the onset of cognitive loss; and, for each individual, it should be redirected to a life-long defense of their brain.<\/jats:p>","DOI":"10.3233\/jad-230429","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T12:26:22Z","timestamp":1684844782000},"page":"51-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Best Medicine for Dementia: The Life-Long Defense of the Brain"],"prefix":"10.1177","volume":"94","author":[{"given":"Marcus J.","family":"Andersson","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Stone","sequence":"additional","affiliation":[{"name":"School of Medical Sciences and Faculty of Medicine and Health, University of 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