{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:14:47Z","timestamp":1777396487822,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,10,10]]},"abstract":"<jats:p>Background: Elevated tau phosphorylation has been linked to the Apolipoprotein E (APOE) \u025b4 allele, which is considered one of the most significant genes related to Alzheimer\u2019s disease (AD). However, it is uncertain whether the impact of increased plasma tau phosphorylated at threonine 181 (p-tau181) on memory and executive function decline would be greater among APOE \u025b4 carriers. Objective: To investigate the effects of plasma p-tau181 and APOE \u025b4 on memory and executive function. Methods: The longitudinal analysis included 608 older adults without dementia (aged 72\u00b17 years; 47% female; follow-up period of 1.59\u00b11.47 years) from the ADNI dataset, including 180 individuals with normal cognition and 429 individuals with mild cognitive impairment. Linear mixed-effects models were utilized to assess the contributions of APOE \u025b4 status and plasma p-tau181 to longitudinal changes in memory composite score and executive function composite score. Results: At baseline, the APOE \u025b4+\/Tau+ group exhibited poorer performance in memory composite score and executive function composite score, and an elevated load of cerebrospinal fluid A\u03b2 and tau pathologies. To further understand longitudinal changes, we compared groups directly based on plasma p-tau181 and APOE \u025b4 status (four groups: APOE \u025b4\u2013\/Tau\u2013, APOE \u025b4\u2013\/Tau+, APOE \u025b4+\/Tau\u2013, APOE \u025b4+\/Tau+). Both the memory composite score and executive function composite score showed a significantly greater decline in the APOE \u025b4+\/Tau+ group than in all other groups. Conclusions: Our findings indicate that there is an interaction between plasma p-tau181 levels and APOE \u025b4 status, which contributes to the longitudinal changes of memory and executive function in older adults without dementia.<\/jats:p>","DOI":"10.3233\/jad-230437","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:42:42Z","timestamp":1694526162000},"page":"1509-1518","source":"Crossref","is-referenced-by-count":0,"title":["APOE \u025b4 Status and Plasma p-tau181 Levels May Influence Memory and Executive Function Decline in Older Adults Without Dementia"],"prefix":"10.1177","volume":"95","author":[{"given":"Shanshan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofa","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research and Development, Hangzhou Shansier Medical Technologies Co., Ltd., Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengwei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated 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