{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:13:55Z","timestamp":1782224035127,"version":"3.54.5"},"reference-count":128,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Different investigations lead to the urgent need to generate validated clinical protocols as a tool for medical doctors to orientate patients under risk for a preventive approach to control Alzheimer\u2019s disease. Moreover, there is consensus that the combined effects of risk factors for the disease can be modified according to lifestyle, thus controlling at least 40% of cases. The other fraction of cases are derived from candidate genes and epigenetic components as a relevant factor in AD pathogenesis. At this point, it appears to be of critical relevance the search for molecular biomarkers that may provide information on probable pathological events and alert about early detectable risks to prevent symptomatic events of the disease. These precocious detection markers will then allow early interventions of non-symptomatic subjects at risk. Here, we summarize the status and potential avenues of prevention and highlight the usefulness of biological and reliable markers for AD.<\/jats:p>","DOI":"10.3233\/jad-230454","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:43:33Z","timestamp":1696333413000},"page":"439-457","source":"Crossref","is-referenced-by-count":8,"title":["Toward Prevention and Reduction of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"96","author":[{"given":"Antonia","family":"Gonz\u00e1lez-Madrid","sequence":"first","affiliation":[{"name":"International Center for Biomedicine \u2013 ICC and Faculty of Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Calf\u00edo","sequence":"additional","affiliation":[{"name":"International Center for Biomedicine \u2013 ICC and Faculty of Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"International Center for Biomedicine \u2013 ICC and Faculty of Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"L\u00fcttges","sequence":"additional","affiliation":[{"name":"International Center for Biomedicine \u2013 ICC and Faculty of Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo B.","family":"Maccioni","sequence":"additional","affiliation":[{"name":"International Center for Biomedicine \u2013 ICC and Faculty of Sciences, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230454_ref1","doi-asserted-by":"crossref","unstructured":"(2023) 2023 Alzheimer\u2019s disease facts and figures. 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