{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:25:44Z","timestamp":1779362744102,"version":"3.51.4"},"reference-count":81,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A carbohydrate-restricted diet aimed at lowering insulin levels has the potential to slow Alzheimer\u2019s disease (AD). Restricting carbohydrate consumption reduces insulin resistance, which could improve glucose uptake and neural health. A hallmark feature of AD is widespread cortical thinning; however, no study has demonstrated that lower net carbohydrate (nCHO) intake is linked to attenuated cortical atrophy in patients with AD and confirmed amyloidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We tested the hypothesis that individuals with AD and confirmed amyloid burden eating a carbohydrate-restricted diet have thicker cortex than those eating a moderate-to-high carbohydrate diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 31 patients (mean age 71.4\u00b17.0 years) with AD and confirmed amyloid burden were divided into two groups based on a 130\u200ag\/day nCHO cutoff. Cortical thickness was estimated from T1-weighted MRI using FreeSurfer. Cortical surface analyses were corrected for multiple comparisons using cluster-wise probability. We assessed group differences using a two-tailed two-independent sample t-test. Linear regression analyses using nCHO as a continuous variable, accounting for confounders, were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The lower nCHO group had significantly thicker cortex within somatomotor and visual networks. Linear regression analysis revealed that lower nCHO intake levels had a significant association with cortical thickness within the frontoparietal, cingulo-opercular, and visual networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Restricting carbohydrates may be associated with reduced atrophy in patients with AD. Lowering nCHO to under 130\u200ag\/day would allow patients to follow the well-validated MIND diet while benefiting from lower insulin levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230458","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:16:09Z","timestamp":1695384969000},"page":"329-342","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer\u2019s Disease: A Small Sample Study"],"prefix":"10.1177","volume":"96","author":[{"given":"Jennifer E.","family":"Bramen","sequence":"first","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"},{"name":"Saint John\u2019s Cancer Institute at Providence Saint John\u2019s Health Center, Santa Monica, CA, USA"},{"name":"Providence Saint John\u2019s Health Center, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Siddarth","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"},{"name":"David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S.","family":"Popa","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin T.","family":"Kress","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"},{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly K.","family":"Rapozo","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Hodes","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"},{"name":"Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarthi S.","family":"Ganapathi","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colby B.","family":"Slyapich","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M.","family":"Glatt","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyron","family":"Pierce","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verna R.","family":"Porter","sequence":"additional","affiliation":[{"name":"Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA"},{"name":"Saint John\u2019s Cancer Institute at Providence Saint John\u2019s Health Center, Santa Monica, CA, USA"},{"name":"Providence Saint John\u2019s Health Center, Santa Monica, CA, 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