{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:08:41Z","timestamp":1785323321691,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Background: Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait, is associated with disability in instrumental activities of daily living. It is unknown whether these functional limitations occur even before this pre-dementia syndrome is diagnosed. Objective: To assess profiles of complex and instrumental activities of daily living in the prodromal stages of MCR. Methods: We examined functional profiles in 46 older adults (mean age 79 years, 59% women) living in the community with normal cognition at baseline who developed MCR over follow-up (\u2018pre-MCR\u2019) with 264 older adults (mean age 75 years, 57% women) who remained cognitively intact over the follow-up period. Results: Pre-MCR individuals had more limitations on complex everyday function at baseline compared to normal controls in multivariable logistic regression models (odds ratio 1.21). Pre-MCR cases at baseline had limitations in handling finances (odds ratio 3.0) and performing hobbies (odds ratio 5.5) as compared to normal controls. Pre-MCR cases had a greater difference in the number of complex functional limitations from baseline to MCR compared to the difference from baseline to final visit for the controls (1.2\u00b13.0 versus 0.5\u00b12.2, p\u200a&lt;\u200a0.001). Conclusions: Limitations in complex everyday tasks arise in the prodromal stages of MCR and can assist in risk prognostication.<\/jats:p>","DOI":"10.3233\/jad-230579","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:16:23Z","timestamp":1697199383000},"page":"695-704","source":"Crossref","is-referenced-by-count":2,"title":["Prodromal Motoric Cognitive Risk Syndrome and Everyday Function"],"prefix":"10.1177","volume":"96","author":[{"given":"Nigel L.","family":"Kravatz","sequence":"first","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dristi","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230579_ref1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/alz.12681","article-title":"Everyday function profiles in prodromal stages of MCI: Prospective cohort study","volume":"19","author":"Verghese","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230579_ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4235\/agmr.20.0001","article-title":"Motoric cognitive risk syndrome: A risk factor for cognitive impairment and dementia in different populations","volume":"24","author":"Meiner","year":"2020","journal-title":"Ann Geriatr Med Res"},{"key":"10.3233\/JAD-230579_ref3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12603-020-1525-y","article-title":"Slow gait, subjective cognitive decline and motoric cognitive risk syndrome: Prevalence and associated factors in community dwelling older adults","volume":"25","author":"Merchant","year":"2021","journal-title":"J Nutr Health Aging"},{"key":"10.3233\/JAD-230579_ref4","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3233\/JAD-210239","article-title":"Walking while talking and prefrontal oxygenation in motoric cognitive risk syndrome: Clinical and pathophysiological aspects","volume":"84","author":"Udina","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-230579_ref5","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/ene.14271","article-title":"Non-memory subjective cognitive concerns predict incident motoric cognitive risk syndrome","volume":"27","author":"Nester","year":"2020","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-230579_ref6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jalz.2019.03.011","article-title":"Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study","volume":"15","author":"Verghese","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230579_ref7","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1111\/j.1532-5415.1996.tb01404.x","article-title":"The relationship between physical performance measures and independence in instrumental activities of daily living. 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