{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:29:44Z","timestamp":1785292184243,"version":"3.55.0"},"reference-count":79,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Deterioration of the oral environment is one of the risk factors for dementia. A previous study of an Alzheimer\u2019s disease (AD) model mouse suggests that tooth loss induces denervation of the mesencephalic trigeminal nucleus and neuroinflammation, possibly leading to accelerated tau dissemination from the nearby locus coeruleus (LC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To elucidate the relevance of oral conditions and amyloid-\u03b2 (A\u03b2) and tau pathologies in human participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We examined the number of remaining teeth and the biofilm\u2013gingival interface index in 24 AD-spectrum patients and 19 age-matched healthy controls (HCs). They also underwent positron emission tomography (PET) imaging of A\u03b2 and tau with specific radiotracers,\n                      <jats:sup>11<\/jats:sup>\n                      C-PiB and\n                      <jats:sup>18<\/jats:sup>\n                      F-PM-PBB3, respectively. All AD-spectrum patients were A\u03b2-positive, and all HCs were A\u03b2-negative. We analyzed the correlation between the oral parameters and radiotracer retention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No differences were found in oral conditions between the AD and HC groups.\n                      <jats:sup>11<\/jats:sup>\n                      C-PiB retentions did not correlate with the oral indices in either group. In AD-spectrum patients, brain-wide, voxel-based image analysis highlighted several regions, including the LC and associated brainstem substructures, as areas where\n                      <jats:sup>18<\/jats:sup>\n                      F-PM-PBB3 retentions negatively correlated with the remaining teeth and revealed the correlation of tau deposits in the LC ( r\u200a=\u200a\u20130.479, p\u200a=\u200a0.018) primarily with the hippocampal and neighboring areas. The tau deposition in none of the brain regions was associated with the periodontal status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings with previous preclinical evidence imply that tooth loss may enhance AD tau pathogenesis, promoting tau spreading from LC to the hippocampal formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230581","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:23:29Z","timestamp":1699961009000},"page":"1253-1265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of Tooth Loss with Alzheimer\u2019s Disease Tau Pathologies Assessed by Positron Emission Tomography"],"prefix":"10.1177","volume":"96","author":[{"given":"Hideki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Tokyo Dental College, Tokyo, Japan"},{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tagai","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"},{"name":"Department of Psychiatry, The Jikei University of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwamu","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Takado","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kokubo","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan"},{"name":"Department of Functional Neurology & Neurosurgery, Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Cell Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazuko K.","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Tokyo Dental College, Tokyo, Japan"},{"name":"Department of Functional 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