{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:06:22Z","timestamp":1784189182186,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:p>Background: Accumulation of amyloid-\u03b2 (A\u03b2) plaques is one of the main features of Alzheimer\u2019s disease (AD). Physical performance has been related to dementia risk and A\u03b2, and it has been hypothesized as one of the mechanisms leading to greater accumulation of A\u03b2. Yet, no evidence synthesis has been performed in humans. Objective: To investigate the association of physical performance with A\u03b2 in humans, including A\u03b2 accumulation on brain, and A\u03b2 abnormalities measured in cerebrospinal fluid (CSF) and blood. Methods: A systematic review with multilevel meta-analysis was performed from inception to June 16th, 2022. Studies were eligible if they examined the association of physical performance with A\u03b2 levels, including the measure of physical performance as a predictor and the measure of A\u03b2 as an outcome in humans. Results: 7 articles including 2,619 participants were included in the meta-analysis. The results showed that physical performance was not associated with accumulation of A\u03b2 in the brain (ES\u200a=\u200a0.01; 95% CI \u20130.21 to 0.24; I2\u200a=\u200a69.9%), in the CSF (ES\u200a=\u200a\u20130.28; 95% CI \u20130.98 to 0.41; I2\u200a=\u200a91.0%) or in the blood (ES\u200a=\u200a\u20130.19; 95% CI \u20130.61 to 0.24; I2\u200a=\u200a99.75%). Significant heterogeneity was found across the results , which posed challenges in arriving at consistent conclusions; and the limited number of studies hindered the opportunity to conduct a moderation analysis. Conclusions: The association between physical performance and A\u03b2 is inconclusive. This uncertainly arises from the limited number of studies, study design limitations, and heterogeneity of measurement approaches. More studies are needed to determine whether physical performance is related to A\u03b2 levels in humans.<\/jats:p>","DOI":"10.3233\/jad-230586","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:33:22Z","timestamp":1700566402000},"page":"1427-1439","source":"Crossref","is-referenced-by-count":4,"title":["Physical Performance and Amyloid-\u03b2 in Humans: A Systematic Review and Meta-Analysis of Observational Studies"],"prefix":"10.1177","volume":"96","author":[{"given":"Patricio","family":"Solis-Urra","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"},{"name":"Nuclear Medicine Services, \u201cVirgen de Las Nieves\u201d, University Hospital, Granada, Spain"},{"name":"Faculty of Education and Social Sciences, Universidad Andres Bello, Vi\u00f1a del Mar, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Liu-Ambrose","sequence":"additional","affiliation":[{"name":"Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada"},{"name":"Aging, Mobility, and Cognitive Health Laboratory, Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco B.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"},{"name":"Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Jyv\u00e4skyl\u00e4, Finland"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk I.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"AdventHealth Research Institute, Neuroscience, Orlando, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Esteban-Cornejo","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"ibs.GRANADA 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