{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:48:38Z","timestamp":1792532918783,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:p>Background: The development of Alzheimer\u2019s disease (AD) can be divided into subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia. Early recognition of pre-AD stages may slow the progression of dementia. Objective: This study aimed to explore functional connectivity (FC) changes of the brain prefrontal cortex (PFC) in AD continuum using functional near-infrared spectroscopy (fNIRS), and to analyze its correlation with cognitive function. Methods: All participants underwent 48-channel fNIRS at resting-state. Based on Brodmann partitioning, the PFC was divided into eight subregions. The NIRSIT Analysis Tool (v3.7.5) was used to analyze mean \u0394HbO2 and FC. Spearman correlation analysis was used to examine associations between FC and cognitive function. Results: Compared with HC group, the mean \u0394HbO2 and FC were different between multiple subregions in the AD continuum. Both mean \u0394HbO2 in the left dorsolateral PFC and average FC decreased sequentially from SCD to MCI to AD groups. Additionally, seven pairs of subregions differed in FC among the three groups: the differences between the MCI and SCD groups were in heterotopic connectivity; the differences between the AD and SCD groups were in left intrahemispheric and homotopic connectivity; whereas the MCI and AD groups differed only in homotopic connectivity. Spearman correlation results showed that FCs were positively correlated with cognitive function. Conclusions: These results suggest that the left dorsolateral PFC may be the key cortical impairment in AD. Furthermore, there are different resting-state prefrontal network patterns in AD continuum, and the degree of cognitive impairment is positively correlated with reduced FC strength.<\/jats:p>","DOI":"10.3233\/jad-230648","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:02:55Z","timestamp":1711108975000},"page":"1287-1300","source":"Crossref","is-referenced-by-count":8,"title":["Correlation Between Prefrontal Functional Connectivity and the Degree of Cognitive Impairment in Alzheimer\u2019s Disease: A Functional Near-Infrared Spectroscopy Study"],"prefix":"10.1177","volume":"98","author":[{"given":"Mengxue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese 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