{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:30Z","timestamp":1777396710365,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Posterior cortical atrophy (PCA) and logopenic progressive aphasia (LPA) are two common atypical Alzheimer\u2019s disease (AD) variants. Little is known about behavioral and neuropsychiatric symptoms or activities of daily living (ADLs) in PCA and LPA, and whether they differ across syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize the behavioral and neuropsychiatric profiles and ADLs of PCA and LPA and compare presence\/absence and severity of symptoms between syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Seventy-eight atypical AD patients, 46 with PCA and 32 with LPA, completed the Neuropsychiatric Inventory Questionnaire (NPI-Q) and Cambridge Behavioral Inventory-Revised (CBI-R) at baseline and longitudinally over-time. Mann-Whitney U and Fisher\u2019s Exact Tests assessed for differences in symptoms between the two syndromes with significance set at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u22640.01. To eliminate demographic differences as confounders the groups were matched, and differences reanalyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PCA were younger at onset (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.006), at time of baseline assessment (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.02) and had longer disease duration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.01). Neuropsychiatric symptoms were common in PCA and LPA, although more common and severe in PCA. At baseline, PCA had a higher NPI-Q total score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.01) and depression subscore (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.01) than LPA. Baseline total CBI-R scores were also higher in PCA than LPA (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.001) with PCA having worse scores in all 10 CBI-R categories. Longitudinally, there was no difference between groups on the NPI-Q. However, on the CBI-R, PCA had faster rates of worsening on self-grooming (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.01) and self-dressing (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.01) compared to LPA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Behavioral and neuropsychiatric symptoms are common in PCA and LPA although these symptoms are more common and severe in PCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230652","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T10:58:30Z","timestamp":1703242710000},"page":"895-908","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral and Neuropsychiatric Differences Across Two Atypical Alzheimer\u2019s Disease Variants: Logopenic Progressive Aphasia and Posterior Cortical Atrophy"],"prefix":"10.1177","volume":"97","author":[{"given":"Carling G.","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tia","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Buciuc","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Medical University of South Carolina","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha Atulkumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nha Trang Thu","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Machulda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.12.018"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190124"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.05.013"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000320506.79811.da"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310107024"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1681041"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140290.80962.BF"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140289.18472.15"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24885"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012322"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu024"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.10.1427"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70289-7"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369062"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.014"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8762-6"},{"key":"e_1_3_5_18_2","first-page":"65","article-title":"Neuropsychiatric symptoms in posteriorcortical atrophy and Alzheimer disease","volume":"29","author":"Su\u00e1rez-Gonz\u00e1lez A","year":"2016","unstructured":"Su\u00e1rez-Gonz\u00e1lezA, CrutchSJ, Franco-Mac\u00edasE, Gil-N\u00e9cigaE (2016) Neuropsychiatric symptoms in posteriorcortical atrophy and Alzheimer disease. J Geriatr PsychiatryNeurol 29, 65\u201371.","journal-title":"J Geriatr PsychiatryNeurol"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714554713"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.5.708"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200625"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.005"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1971"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.079"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/14.6.481"},{"key":"e_1_3_5_30_2","unstructured":"GoodglassH KaplanE BarresiB (2001) Boston Diagnostic Aphasia Examination (3rd ed.) (BDAE-3) Pro-Ed Austin TX."},{"key":"e_1_3_5_31_2","unstructured":"ReyA (1964) The Clinical Psychological Examination Presses Universitaires de France Paris France."},{"key":"e_1_3_5_32_2","doi-asserted-by":"crossref","unstructured":"KerteszA (2007) Western Aphasia Battery\u2013Revised.","DOI":"10.1037\/t15168-000"},{"key":"e_1_3_5_33_2","unstructured":"WarringtonEK (1991) Visual object and space perception battery."},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642009DN20200005"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000767"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000399"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617719001115"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/3.4.313"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25979"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201536"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-230652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-230652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:07Z","timestamp":1777370947000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-230652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,16]]}},"alternative-id":["10.3233\/JAD-230652"],"URL":"https:\/\/doi.org\/10.3233\/jad-230652","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]}}}