{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:48Z","timestamp":1790704188595,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) pathology can be disclosed in vivo using amyloid and tau imaging, unlike non-AD neuropathologies for which no specific markers exist. Objective: We aimed to compare brain hypometabolism and tauopathy to unveil non-AD pathologies. Methods: Sixty-one patients presenting cognitive complaints (age 48\u201390), including 32 with positive AD biomarkers (52%), performed [18F]-Fluorodeoxyglucose (FDG)-PET (brain metabolism) and [18F]-MK-6240-PET (tau). We normalized these images using data from clinically normal individuals (n\u200a=\u200a30), resulting in comparable FDG and tau z-scores. We computed between-patients correlations to evaluate regional associations. For each patient, a predominant biomarker (i.e., Hypometabolism\u200a&gt;\u200aTauopathy or Hypometabolism\u2264Tauopathy) was determined in the temporal and frontoparietal lobes. We computed within-patient correlations between tau and metabolism and investigated their associations with demographics, cognition, cardiovascular risk factors (CVRF), CSF biomarkers, and white matter hypointensities (WMH). Results: We observed negative associations between tau and FDG in 37 of the 68 cortical regions-of-interest (average Pearson\u2019s r\u200a=\u200a\u20130.25), mainly in the temporal lobe. Thirteen patients (21%) had Hypometabolism\u200a&gt;\u200aTauopathy whereas twenty-five patients (41%) had Hypometabolism\u2264Tauopathy. Tau-predominant patients were more frequently females and had greater amyloid burden. Twenty-three patients (38%) had Hypometabolism\u2264Tauopathy in the temporal lobe, but Hypometabolism\u200a&gt;\u200aTauopathy in the frontoparietal lobe. This group was older and had higher CVRF than Tau-predominant patients. Patients with more negative associations between tau and metabolism were younger, had worse cognition, and greater amyloid and WMH burdens. Conclusions: Tau-FDG comparison can help suspect non-AD pathologies in patients presenting cognitive complaints. Stronger Tau-FDG correlations are associated with younger age, worse cognition, and greater amyloid and WMH burdens.<\/jats:p>","DOI":"10.3233\/jad-230696","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T11:37:04Z","timestamp":1702381024000},"page":"421-433","source":"Crossref","is-referenced-by-count":5,"title":["Suspecting Non-Alzheimer\u2019s Pathologies and Mixed Pathologies: A Comparative Study Between Brain Metabolism and Tau Images"],"prefix":"10.1177","volume":"97","author":[{"given":"Vincent","family":"Malotaux","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Colmant","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"},{"name":"Department of Neurology, Saint-Luc University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Quenon","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"},{"name":"Department of Neurology, Saint-Luc University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Huyghe","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"},{"name":"Department of Nuclear Medicine, Saint-Luc University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Dricot","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Ivanoiu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"},{"name":"Department of Neurology, Saint-Luc University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Lhommel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Saint-Luc University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"},{"name":"Department of Neurology, Saint-Luc University Hospital, Brussels, Belgium"},{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"WEL Research Institute, Welbio department, Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230696_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-230696_ref3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer\u2019s disease\u2013lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC 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