{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:08Z","timestamp":1791896348028,"version":"4.3.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hearing loss is associated with cognitive decline and increased risk for Alzheimer\u2019s disease, but the basis of this association is not understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether hearing impairment is associated with advanced brain aging or altered microstructure in areas involved with auditory and cognitive processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>130 participants, (mean 76.4\u00b17.3 years; 65% women) of the Rancho Bernardo Study of Healthy Aging had a screening audiogram in 2003\u20132005 and brain magnetic resonance imaging in 2014\u20132016. Hearing ability was defined as the average pure tone threshold (PTA) at 500, 1000, 2000, and 4000\u200aHz in the better-hearing ear. Brain-predicted age difference (Brain-pad) was calculated as the difference between brain-predicted age based on a validated structural imaging biomarker of brain age, and chronological age. Regional diffusion metrics in temporal and frontal cortex regions were obtained from diffusion-weighted MRIs. Linear regression analyses adjusted for age, gender, education, and health-related measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PTAs were not associated with brain-PAD (\u03b2=\u200a0.09; 95% CI: \u20130.084 to 0.243; p\u200a=\u200a0.34). PTAs were associated with reduced restricted diffusion and increased free water diffusion primarily in right hemisphere temporal and frontal areas (restricted diffusion: \u03b2s\u200a=\u200a\u20130.21 to \u20130.30; 95% CIs from \u20130.48 to \u20130.02; ps\u200a&lt;\u200a0.03; free water: \u03b2s\u200a=\u200a0.18 to 0.26; 95% CIs 0.01 to 0.438; ps\u200a&lt;\u200a0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Hearing impairment is not associated with advanced brain aging but is associated with differences in brain regions involved with auditory processing and attentional control. It is thus possible that increased dementia risk associated with hearing impairment arises, in part, from compensatory brain changes that may decrease resilience.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230767","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:25:16Z","timestamp":1699363516000},"page":"1163-1172","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Elevated Pure Tone Thresholds Are Associated with Altered Microstructure in Cortical Areas Related to Auditory Processing and Attentional Allocation"],"prefix":"10.1177","volume":"96","author":[{"given":"Linda K.","family":"McEvoy","sequence":"first","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA"},{"name":"Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, 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