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The T-maze test was used to assess spatial memory once a month. After 6 months, histological alterations of the frontal and entorhinal cortices, CA1, subiculum, and amygdala were analyzed by performing Congo red, Bielschowsky, and Golgi impregnation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cognitive results in the T-maze showed memory impairment from the third month of V\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>5<\/jats:sub>\n                      inhalation. We also noted NFTs, A\u03b2 plaque accumulation in the vascular endothelium and pyramidal neurons, dendritic spine, and neuronal loss in all the analyzed structures, CA1 being the most affected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This model characterizes neurodegenerative changes specific to AD. Our model is compatible with Braak AD stage IV, which represents a moment where it is feasible to propose therapies that have a positive impact on stopping neuronal damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230818","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:16:19Z","timestamp":1713269779000},"page":"121-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Histological and Memory Alterations in an Innovative Alzheimer\u2019s Disease Animal Model by Vanadium Pentoxide Inhalation"],"prefix":"10.1177","volume":"99","author":[{"given":"Claudia","family":"Dorado-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Neuromorphology Lab, Facultad de Estudios Superiores Iztacala, UNAM, Los Reyes Iztacala, Tlalnepantla, Edo. 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