{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:53Z","timestamp":1788909233821,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Background: The perplex interrelation between circulating extracellular vesicles (cEVs) and amyloid-\u03b2 (A\u03b2) deposits in the context of Alzheimer\u2019s disease (AD) is poorly understood. Objective: This study aims to 1) analyze the possible cross-linkage of the neurotoxic amyloid-\u03b2 oligomers (oA\u03b2) to the human cEVs, 2) identify cEVs corona proteins associated with oA\u03b2 binding, and 3) analyze the distribution and expression of targeted cEVs proteins in preclinical participants converted to AD 5 years later (Pre-AD). Methods: cEVs were isolated from 15 Pre-AD participants and 15 healthy controls selected from the Canadian Study of Health and Aging. Biochemical, clinical, lipid, and inflammatory profiles were measured. oA\u03b2 and cEVs interaction was determined by nanoparticle tracking analysis and proteinase K digestion. cEVs bound proteins were determined by ELISA. Results: oA\u03b2 were trapped by cEVs and were topologically bound to their external surface. We identified surface-exposed proteins functionally able to conjugate oA\u03b2 including apolipoprotein J (apoJ), apoE and RAGE, with apoJ being 30- to 130-fold higher than RAGE and apoE, respectively. The expression of cEVs apoJ was significantly lower in Pre-AD up to 5 years before AD onset. Conclusion: Our findings suggest that cEVs might participate in oA\u03b2 clearance and that early dysregulation of cEVs could increase the risk of conversion to AD.<\/jats:p>","DOI":"10.3233\/jad-230823","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:17:02Z","timestamp":1697199422000},"page":"813-825","source":"Crossref","is-referenced-by-count":4,"title":["Implication of Circulating Extracellular Vesicles-Bound Amyloid-\u03b242 Oligomers in the Progression of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"96","author":[{"given":"Mohamed Ra\u00e2fet","family":"Ben Khedher","sequence":"first","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9-Biotechnologie, Laval, QC, Canada"},{"name":"Institute of Nutrition and Functional Foods, Qu\u00e9bec, QC, Canada"},{"name":"Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Haddad","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9-Biotechnologie, Laval, QC, Canada"},{"name":"Institute of Nutrition and Functional Foods, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Fulop","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geriatric Division, Research Center on Aging, Sherbrooke University, Sherbrooke, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Laurin","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods, Qu\u00e9bec, QC, Canada"},{"name":"Centre d\u2019Excellence Sur le Vieillissement de Qu\u00e9bec, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Centre, VI-TAM-Centre de Recherche en Sant\u00e9 Durable, Qu\u00e9bec, QC, Canada"},{"name":"Faculty of Pharmacy, Laval University, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ramassamy","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9-Biotechnologie, Laval, QC, Canada"},{"name":"Institute of Nutrition and Functional Foods, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230823_ref1","doi-asserted-by":"crossref","unstructured":"(2023) 2023 Alzheimer\u2019s disease facts and figures. 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