{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:13Z","timestamp":1777396933086,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nursing home placement (NHP) can be the final step of patients with Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to identify NHP predictors among 508 people with dementia with a 3-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed data from the international observational RECage study, involving 508 people with especially Alzheimer\u2019s disease and comparing a cohort enrolled by five centers with a Special Care Unit for BPSD (behavioral and psychological symptoms of dementia) and another one enrolled by six centers lacking this facility. The tertiary objective of the study was to assess the possible role of the SCU-B in delaying NHP. We assessed the relationship of the baseline characteristics with NHP by means of univariate analysis followed by Cox\u2019s multivariate model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients\u2019 mean age was 78.1 years, 54.9% were women. Diagnosis mean age was 75.4 (\u00b18.32) years; the main diagnosis was Alzheimer\u2019s disease (296; 58.4%). During follow-up, 96 (18.9%) patients died and 153 (30.1%) were institutionalized without a statistically significant difference between the two cohorts (p\u200a=\u200a0.9626). The mean NHP time was 902 (95% CI: 870\u2013934). The multivariable analysis without death as a competing risk retained four independent predictors of NHP: age increase (hazard ratio (HR)\u200a=\u200a1.023, 95% CI: 1.000\u20131.046), patient education level increase (HR\u200a=\u200a1.062, 95% CI: 1.024\u20131.101), Neuropsychiatric Inventory total increase (HR\u200a=\u200a1.018; 95% CI: 1.011\u20131.026), and total Mini-Mental State Examination as a favorable factor (HR\u200a=\u200a0.948, 95% CI: 0.925\u20130.971). Gender (females versus males: HR\u200a=\u200a1.265, 95% CI: 0.899\u20131.781) was included in the final Cox\u2019s model for adjusting the estimates for.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our data partially agree with the predictors of NHP in literature including the effect of high education level. No caregivers\u2019 factors were statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Clinical trial registration:<\/jats:title>\n                    <jats:p>NCT03507504.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230878","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:54:06Z","timestamp":1710248046000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of Nursing Home Placement in a Cohort of European People with Alzheimer\u2019s Disease and Other Dementia Cases Enrolled in SCU-B or Non SCU-B Centers: The RECage Study"],"prefix":"10.1177","volume":"98","author":[{"given":"Bruno Mario","family":"Cesana","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics \u201cGiulio A. Maccacaro\u201d Faculty of Medicine and Surgery, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre","family":"Bergh","sequence":"additional","affiliation":[{"name":"Research Centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway (SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Department of Neurology with Neurosurgical Activity \u201cCarlo Poma\u201d Hospital, ASST di Mantova, Mantua, Italy (non-SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Cognat","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Centre, Lariboisi\u00e8re-Fernand Widal Hospital GHU AP-HP Nord, Universit\u00e9 Paris-Diderot, Paris, France (non-SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fabbo","sequence":"additional","affiliation":[{"name":"Department of Primary Care, Geriatric Service-Cognitive Disorders and Dementia, Local Health Authority of Modena (AUSL), Modena, Italy (SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fascendini","sequence":"additional","affiliation":[{"name":"FERB Alzheimer Centre, Gazzaniga, Italy (SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Rehabilitation, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland (SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany (SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Handels","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Jori","sequence":"additional","affiliation":[{"name":"Mediolanum Cardio Research, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Mecocci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy"},{"name":"NVS Department, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden (non-SCU-B)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Merlo","sequence":"additional","affiliation":[{"name":"Neurological Unit (PM), U.V.A. 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