{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:02:55Z","timestamp":1779357775562,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:p>Background: The associations between neuropsychiatric symptoms (NPSs) and Alzheimer\u2019s disease (AD) have been well-studied, yet gaps remain. Objective: We aimed to examine the associations of four subsyndromes (hyperactivity, psychosis, affective symptoms, and apathy) of NPSs with cognition, neurodegeneration, and AD pathologies. Methods: Totally 1,040 non-demented elderly (48.07% males) from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) were included. We assessed the relationships between NPSs and AD neuropathologies, cognition, neurodegeneration, and clinical correlates in cross-sectional and longitudinal via multiple linear regression, linear mixed effects, and Cox proportional hazard models. Causal mediation analyses were conducted to explore the mediation effects of AD pathologies on cognition and neurodegeneration. Results: We found that individuals with hyperactivity, psychosis, affective symptoms, or apathy displayed a poorer cognitive status, a lower CSF amyloid-\u03b2 (A\u03b2) level and a higher risk of clinical conversion (p\u200a&lt;\u200a0.05). Hyperactivity and affective symptoms were associated with increasing cerebral A\u03b2 deposition (p\u200a&lt;\u200a0.05). Except psychosis, the other three subsyndromes accompanied with faster atrophy of hippocampal volume (p\u200a&lt;\u200a0.05). Specific NPSs were predominantly associated with different cognitive domains decline through an 8-year follow-up (p\u200a&lt;\u200a0.05). Moreover, the relationships between NPSs and cognitive decline, neurodegeneration might be associated with A\u03b2, the mediation percentage varied from 6.05% to 17.51% (p\u200a&lt;\u200a0.05). Conclusions: NPSs could be strongly associated with AD. The influences of NPSs on cognitive impairments, neurodegeneration might be partially associated with A\u03b2.<\/jats:p>","DOI":"10.3233\/jad-230918","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:22:09Z","timestamp":1702988529000},"page":"471-484","source":"Crossref","is-referenced-by-count":7,"title":["Amyloid Pathology Modulates the Associations of Neuropsychiatric Symptoms with Cognitive Impairments and Neurodegeneration in Non-Demented Elderly"],"prefix":"10.1177","volume":"97","author":[{"given":"Yun","family":"Guo","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Weifang Medical University, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Yi","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Dalian, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Hospital, University of Health and Rehabilitation Sciences, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Shan","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Weifang Medical University, Weifang, 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