{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:19:53Z","timestamp":1777396793460,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,1,30]]},"abstract":"<jats:p>We analyzed Lewy body (LB) pathology in 18 autosomal dominant Alzheimer\u2019s disease (ADAD) brains via immunohistochemistry. Real-time quaking induced conversion was used to detect misfolded \u03b1-synuclein (\u03b1-syn) in 18 living ADAD cerebrospinal fluid (CSF) samples. Concomitant LB pathology was present in 44% ADAD brains. Only 6% CSF samples were positive for misfolded \u03b1-syn. In an additional AD sample, all patients with confirmed LB presented misfolded \u03b1-syn in postmortem CSF regardless of the LB staging. In conclusion, misfolded \u03b1-syn in CSF was scarce in symptomatic living ADAD individuals, in contrast to postmortem brain tissue. These results suggest late appearance of LB pathology in ADAD.<\/jats:p>","DOI":"10.3233\/jad-230919","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:11:28Z","timestamp":1705403488000},"page":"1091-1096","source":"Crossref","is-referenced-by-count":2,"title":["Misfolded \u03b1-Synuclein in Autosomal Dominant Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"97","author":[{"given":"Laura","family":"Fort-Aznar","sequence":"first","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona, FRCB-IDIBAPS, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Molina-Porcel","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona, FRCB-IDIBAPS, Barcelona, Spain"},{"name":"Neurological Tissue Bank, Biobank-Hospital 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