{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:07:39Z","timestamp":1791472059186,"version":"4.3.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:p>Background: Plasma biomarkers have emerged as a promising approach for characterizing pathophysiology in mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD). Objective: We aimed to characterize plasma biomarkers for AD and neurodegeneration across the AD clinical continuum, and to assess their ability to differentiate between AD, MCI, and normal cognition. Methods: This population-based study engaged 1,446 rural-dwelling older adults (age \u226560 years, 61.0% women) derived from MIND-China; of these, 402 were defined with MCI and 142 with AD. Plasma amyloid-\u03b2 (A\u03b2), total tau (t-tau), and neurofilament light chain (NfL) concentrations were analyzed using the Simoa platform. Data were analyzed using linear and logistic regression models, and receiver operating characteristic (ROC) analysis. Results: Across the AD clinical spectrum, plasma A\u03b240 and NfL increased, whereas A\u03b242\/A\u03b240 ratio decreased. Plasma t-tau was higher in people with AD dementia than those with MCI or normal cognition. Plasma NfL outperformed other biomarkers in differentiating AD from normal cognition (area under the ROC curve [AUC]\u200a=\u200a0.75), but all plasma biomarkers performed poorly to distinguish MCI from normal cognition (AUC &lt;0.60). Plasma NfL in combination with age, sex, education, and APOE genotype yielded the AUC of 0.87 for differentiating between AD and normal cognition, 0.79 between AD and MCI, and 0.64 between MCI and normal cognition. Conclusions: In this Chinese population, AD plasma biomarkers vary by age, sex, and APOE genotype. Plasma A\u03b2, t-tau, and NfL differ across the AD clinical spectrum, and plasma NfL appears to be superior to plasma A\u03b2 and t-tau for defining the clinical spectrum.<\/jats:p>","DOI":"10.3233\/jad-230932","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T11:23:42Z","timestamp":1698405822000},"page":"845-858","source":"Crossref","is-referenced-by-count":27,"title":["Plasma Amyloid-\u03b2, Total Tau, and Neurofilament Light Chain Across the Alzheimer\u2019s Disease Clinical Spectrum: A Population-Based Study"],"prefix":"10.1177","volume":"96","author":[{"given":"Yi","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Li","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. 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China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China"},{"name":"Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging in Shandong First Medical University, Ministry of Education of the People\u2019s Republic of China, Jinan, Shandong, P.R. China"},{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden"},{"name":"Theme Inflammation and Aging, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. 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