{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:08:18Z","timestamp":1784740098259,"version":"3.55.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer-associated neuronal thread protein (AD7c-NTP) has been demonstrated to have high diagnostic accuracy in differentiating Alzheimer\u2019s disease (AD) patients from healthy individuals. However, it is yet unclear whether exercise can lower the level of AD7c-NTP in urine among active Korean elderly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the effect of exercise on AD7c-ntp levels in urine and cognitive function among active Korean elderly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In total, 40 Korean elderly (\u226565 years) were divided into Active Control group (CG,\n                      <jats:italic>n<\/jats:italic>\n                      \u200a=\u200a10), Aerobic exercise group (AG,\n                      <jats:italic>n<\/jats:italic>\n                      \u200a=\u200a18), and combined Resistance\/Aerobic exercise group (RAG,\n                      <jats:italic>n<\/jats:italic>\n                      \u200a=\u200a12). A total of 12 weeks of exercise intervention was implemented. At week 0 and 12, cognitive performance (Korean Mini-Mental State Examination, Korean-Color Word Stroop test), grip strength, and body composition (muscle mass and body fat percentage) were measured. Also, a morning urine sample was obtained from each subject. The level of AD7c-NTP was measured using competitive enzyme-linked immunosorbent assay (ELISA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After 12 weeks of exercise intervention, there was a significant difference of AD7c-NTP levels between RAG and CG (\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.026), AG and CG (\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.032), respectively. Furthermore, the AD7c-NTP levels in urine showed negative correlation with K-MMSE scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u200a=\u200a\u20130.390,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.013) and grip strength (\n                      <jats:italic>r<\/jats:italic>\n                      \u200a=\u200a\u20130.376,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.017), among all participants after exercise intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first study to investigate urine biomarker through exercise intervention. In future stuides, participants who have low cognitive function and low activity levels need to be recruited to observe more significant \u2018Exercise\u2019 effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-230946","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T11:12:40Z","timestamp":1713870760000},"page":"345-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Exercise on Urinary AD7c-NTP (Alzheimer-Associated Neuronal Thread Protein) Levels and Cognitive Function Among Active Korean Elderly: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"99","author":[{"given":"Donghyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parivash","family":"Jamrasi","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunho","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seohyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuseon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea"},{"name":"Institute of Sport Science, Seoul National University, Seoul, Republic of Korea"},{"name":"Institute on Aging, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1179573520907397"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000191420.61260.a8"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.5607\/en20042"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.182"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2015.11.3.212"},{"key":"e_1_3_5_7_2","doi-asserted-by":"crossref","unstructured":"AngevarenM AufdemkampeG VerhaarHJ AlemanA VanheesL (2008) Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. 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