{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:09Z","timestamp":1777396689321,"version":"3.51.4"},"reference-count":101,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:p>Background: Attitudes, motivations, and barriers to pre-symptomatic screening for Alzheimer\u2019s disease (AD) in the general population are unclear, and validated measurement tools are lacking. Objective: Translation and validation of the German version of the \u201cPerceptions regarding pRE-symptomatic Alzheimer\u2019s Disease Screening\u201d (PRE-ADS) questionnaire. Methods: A convenience sample (N\u200a=\u200a256) was recruited via an online platform. Validation of the PRE-ADS-D consisted of assessments of reliability, structural validity using Principal Component Analysis (PCA) and Exploratory Factor Analysis (EFA) and construct validity using known-group tests. A subscale \u201cAcceptability of Screening\u201d, with 5 PRE-ADS-D items, was extracted to measure acceptance of screening in clinical practice. The STROBE checklist was used for reporting. Results: EFA revealed a three-factor model for the PRE-ADS-D. Acceptable to good internal consistency was found for the 25-item scale (\u03b1=\u200a0.78), as well as for the three factors \u201cConcerns about Screening\u201d (\u03b1=\u200a0.85), \u201cIntention to be Screened\u201d (\u03b1=\u200a0.87), and \u201cPreventive Health Behaviors\u201d (\u03b1=\u200a0.81). Construct validity was confirmed for both the 25-item PRE-ADS-D and the \u201cAcceptability of Screening\u201d scale (\u03b1=\u200a0.91). Overall, 51.2% of the participants showed a preference for screening. Non-parametric tests were conducted to further explore group differences of the sample. Conclusions: The PRE-ADS-D is a reliable and valid tool to measure attitudes, motives, and barriers regarding pre-symptomatic dementia screening in the German-speaking general population. Additionally, the subscale \u201cAcceptability of Screening\u201d demonstrated good construct validity and reliability, suggesting its promising potential as a practical tool in clinical practice.<\/jats:p>","DOI":"10.3233\/jad-230961","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:06:36Z","timestamp":1704193596000},"page":"309-325","source":"Crossref","is-referenced-by-count":2,"title":["Validation of the \u201cPerceptions Regarding pRE-Symptomatic Alzheimer\u2019s Disease Screening\u201d (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening"],"prefix":"10.1177","volume":"97","author":[{"given":"Ioanna Antigoni","family":"Angelidou","sequence":"first","affiliation":[{"name":"Network Aging Research, Heidelberg University, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Stocker","sequence":"additional","affiliation":[{"name":"Network Aging Research, Heidelberg University, Heidelberg, Germany"},{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Beyreuther","sequence":"additional","affiliation":[{"name":"Network Aging Research, Heidelberg University, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Teichmann","sequence":"additional","affiliation":[{"name":"Network Aging Research, Heidelberg University, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-230961_ref1","unstructured":"Alzheimer\u2019s Disease International (2021) World Alzheimer Report 2021: Journey through the diagnosis of dementia . 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