{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:21:01Z","timestamp":1777396861326,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,2,13]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The increasing interest in early identification of people at risk of developing dementia, has led to the development of numerous models aimed at estimating the likelihood of progression from mild cognitive impairment (MCI) to dementia. It is important to study both the need for and possible outcomes related with such prediction models, including the impact of risk predictions on perceived quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to quantify the impact that receiving a risk prediction on progression from MCI to dementia has on QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A Discrete Choice Experiment (DCE) and Time Trade Off (TTO) study were performed. Participants completed choice tasks related to dementia prognosis while imagining having MCI. We collected DCE data by an online survey, and TTO data via videoconferencing interviews. DCE data were analyzed using a mixed multinomial logit model and were anchored to a health state utility scale using mean observed TTO valuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>296 people participated in the DCE and 42 in the TTO. Moderate and high predicted dementia risks were associated with decrements in utility (\u20130.05 and \u20130.18 respectively), compared to no prognostic information. Low predicted risk was associated with an increase in utility (0.06), as well as the availability of medication or lifestyle interventions (0.05 and 0.13 respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study shows a significant impact of dementia risk predictions on QoL and highlights the importance of caution when sharing information about expected MCI disease courses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231037","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T13:30:14Z","timestamp":1707226214000},"page":"1829-1840","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Information on Progression to Dementia: Quantification of the Impact on Quality of Life"],"prefix":"10.1177","volume":"97","author":[{"given":"Robin Jeanna","family":"Vermeulen","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Roudijk","sequence":"additional","affiliation":[{"name":"EuroQol Research Foundation, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim Martin","family":"Govers","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maroeska Mariet","family":"Rovers","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel Gerardus Maria","family":"Olde Rikkert","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Radboudumc Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Franciscus Martinus","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Center for Economic Evaluations, Trimbos Institute, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0266-9"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612461679"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002609"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01326.x"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000055"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21326"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1159\/000354370"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318212"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.840386"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180638"},{"key":"ref016","unstructured":"DrummondMF, SculpherMJ, ClaxtonK, StoddartGL, TorranceGW (2015) Methods for the Economic Evaluation of Health Care Programmes. 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