{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:09:05Z","timestamp":1790190545690,"version":"4.1.0"},"reference-count":75,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:p>Background: While various biomarkers of Alzheimer\u2019s disease (AD) have been associated with general cognitive function, their association to visual-perceptive function across the AD spectrum warrant more attention due to its significant impact on quality of life. Thus, this study explores how AD biomarkers are associated with decline in this cognitive domain. Objective: To explore associations between various fluid and imaging biomarkers and visual-based cognitive assessments in participants across the AD spectrum. Methods: Data from participants (N\u200a=\u200a1,460) in the Alzheimer\u2019s Disease Neuroimaging Initiative were analyzed, including fluid and imaging biomarkers. Along with the Mini-Mental State Examination (MMSE), three specific visual-based cognitive tests were investigated: Trail Making Test (TMT) A and TMT B, and the Boston Naming Test (BNT). Locally estimated scatterplot smoothing curves and Pearson correlation coefficients were used to examine associations. Results: MMSE showed the strongest correlations with most biomarkers, followed by TMT-B. The p-tau181\/A\u03b21\u201342 ratio, along with the volume of the hippocampus and entorhinal cortex, had the strongest associations among the biomarkers. Conclusions: Several biomarkers are associated with visual processing across the disease spectrum, emphasizing their potential in assessing disease severity and contributing to progression models of visual function and cognition.<\/jats:p>","DOI":"10.3233\/jad-231084","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T14:02:53Z","timestamp":1714140173000},"page":"623-637","source":"Crossref","is-referenced-by-count":4,"title":["Visual Functions Are Associated with Biomarker Changes in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"99","author":[{"given":"Ashar","family":"Memon","sequence":"first","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Biomedical Engineering Program, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Departments of Clinical Neurosciences, Psychiatry, Community Health Sciences, and Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils D.","family":"Forkert","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Departments of Clinical Neurosciences, Psychiatry, Community Health Sciences, and Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Departments of Clinical Neurosciences, Psychiatry, Community Health Sciences, and Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-231084_ref1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","article-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","volume":"66","author":"Schneider","year":"2009","journal-title":"Ann 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disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-231084_ref5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.3233\/JAD-231084_ref6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/JAD-221160","article-title":"Attitudes of neurologists toward the use of biomarkers in the diagnosis of early Alzheimer\u2019s disease","volume":"93","author":"Fortea","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-231084_ref7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jalz.2014.06.006","article-title":"The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey","volume":"11","author":"Bocchetta","year":"2015","journal-title":"Alzheimers 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Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"3","author":"Ritchie","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-231084_ref44","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jalz.2018.01.010","article-title":"CSF biomarkers of Alzheimer\u2019s disease concord with amyloid-beta PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts","volume":"14","author":"Hansson","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-231084_ref45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jalz.2015.05.002","article-title":"Magnetic resonance imaging in Alzheimer\u2019s Disease Neuroimaging Initiative 2","volume":"11","author":"Jack","year":"2015","journal-title":"Alzheimers 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A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-231084_ref54","doi-asserted-by":"crossref","first-page":"P187","DOI":"10.1093\/geronb\/57.2.P187","article-title":"Usefulness of a 15-item version of the Boston Naming Test in neuropsychological assessment of low-educational elders with dementia","volume":"57","author":"Calero","year":"2002","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.3233\/JAD-231084_ref55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/arclin\/acy025","article-title":"Trail-Making Test Part B: Evaluation of the efficiency score for assessing floor-level change in Veterans","volume":"34","author":"Smith Watts","year":"2019","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-231084_ref58","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/23279095.2020.1774378","article-title":"Impaired or invalid? Limitations of assessing performance validity using the Boston Naming Test","volume":"29","author":"Abramson","year":"2022","journal-title":"Appl Neuropsychol Adult"},{"key":"10.3233\/JAD-231084_ref59","first-page":"CD011145","article-title":"Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations","volume":"2016","author":"Creavin","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3233\/JAD-231084_ref60","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/01.JGP.0000221510.33817.86","article-title":"Comonparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder\u2013a pilot study","volume":"14","author":"Tariq","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-231084_ref61","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1532-5415.1992.tb01804.x","article-title":"The Mini-Mental State Examination: Identifying the most efficient variables for detecting cognitive impairment in the elderly","volume":"40","author":"Braekhus","year":"1992","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-231084_ref62","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1001\/archneur.1994.00540210088017","article-title":"Discrimination between stages of Alzheimer\u2019s disease with subsets of Mini-Mental State Examination items. An analysis of Consortium to Establish a Registry for Alzheimer\u2019s Disease data","volume":"51","author":"Fillenbaum","year":"1994","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-231084_ref63","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1038\/s41598-020-70410-6","article-title":"Anatomy and white matter connections of the fusiform gyrus","volume":"10","author":"Palejwala","year":"2020","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-231084_ref64","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1073\/pnas.0401679101","article-title":"The anatomy of semantic knowledge: Medial vs. lateral temporal lobe","volume":"101","author":"Levy","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-231084_ref65","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1212\/WNL.58.8.1188","article-title":"MRI measures of entorhinal cortex vs hippocampus in preclinical 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