{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:48:28Z","timestamp":1789015708605,"version":"build-2803163510"},"reference-count":102,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>Biomarkers for predicting Alzheimer\u2019s disease (AD) are advancing and their implementation in various healthcare systems is imminent. There is a need for ethical standards addressing information needs, socio-ethical concerns, and expectations of healthy and at-risk persons. We present an ethical approach that integrates different existing ethical frameworks and discussion of our empirical, cross-cultural findings in a multi-layered perspective by addressing three levels. The micro-level focuses on the communication between counseling professionals, persons at risk or in an early stage of dementia, and family members. The meso-level addresses interprofessional cooperation and exchange as a key element for best person-centered care. The macro-level considers public health promotion, the media, and public-funded research. This approach allows to address key ethical concepts including beneficence, non-maleficence, autonomy, informational self-determination, empowerment, and justice. Our contribution specifically examines the ethical challenges associated with AD prediction by means of biomarkers, based on insights from a German-Israeli comparison, and promotes a transdisciplinary discussion across different healthcare contexts. We propose a reflection on three levels to go beyond the clinical counseling context and to consider the rapidly evolving field of biomarkers in the coming years. Our ethical-practical recommendations should not be considered final, but rather procedural and will require continuous adaptation regarding culturally varying practices, new algorithms, meta-analyses, and re-evaluation of established recommendations.<\/jats:p>","DOI":"10.3233\/jad-231137","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:26:35Z","timestamp":1726226795000},"page":"1063-1081","source":"Crossref","is-referenced-by-count":8,"title":["Moving Towards Ethical-Practical Recommendations for Alzheimer\u2019s Disease Prediction: Addressing Interindividual, Interprofessional, and Societal Aspects"],"prefix":"10.1177","volume":"101","author":[{"given":"Silke","family":"Schicktanz","sequence":"first","affiliation":[{"name":"Department of Medical Ethics and History of Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fcmr\u00fct","family":"Alpinar-Segawa","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and History of Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Institute for Ethics, History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Ulitsa","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and History of Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Department of Community Mental Health, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and History of Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Community Mental Health, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-231137_ref1","unstructured":"World Health Organization. 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