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Furthermore, there is currently no medication to completely cure AD patients. Rapamycin has been clinically demonstrated to postpone the aging process in mice and improve learning and memory abilities in animal models of AD. Therefore, rapamycin has the potential to be significant in the discovery and development of drugs for AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The main objective of this systematic review and meta-analysis was to investigate the effects and mechanisms of rapamycin on animal models of AD by examining behavioral indicators and pathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Six databases were searched and 4,277 articles were retrieved. In conclusion, 13 studies were included according to predefined criteria. Three authors independently judged the selected literature and methodological quality. Use of subgroup analyses to explore potential mechanistic effects of rapamycin interventions: animal models of AD, specific types of transgenic animal models, dosage, and periodicity of administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results of Morris Water Maze (MWM) behavioral test showed that escape latency was shortened by 15.60\u200aseconds with rapamycin therapy, indicating that learning ability was enhanced in AD mice; and the number of traversed platforms was increased by 1.53 times, indicating that the improved memory ability significantly corrected the memory deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Rapamycin therapy reduced age-related plaque deposition by decreasing A\u03b2PP production and down-regulating \u03b2-secretase and \u03b3-secretase activities, furthermore increased amyloid-\u03b2 clearance by promoting autophagy, as well as reduced tau hyperphosphorylation by up-regulating insulin-degrading enzyme levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231249","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T12:55:00Z","timestamp":1713531300000},"page":"53-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer\u2019s Disease: A Systematic Review and Meta-analysis of Preclinical Studies"],"prefix":"10.1177","volume":"99","author":[{"given":"Jie","family":"Cai","sequence":"first","affiliation":[{"name":"School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 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