{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:15:06Z","timestamp":1777396506469,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:p>Background: Early detection of Alzheimer\u2019s disease (AD) is a key component for the success of the recently approved lecanemab and aducanumab. Patients with neuroinflammation-related conditions are associated with a higher risk for developing AD. Objective: Investigate the incidence of AD among patients with neuroinflammation-related conditions including epilepsy, hemorrhage stroke, multiple sclerosis (MS), and traumatic brain injury (TBI). Methods: We used Optum\u2019s de-identified Clinformatics Data Mart Database (CDM). We derived covariate-matched cohorts including patients with neuroinflammation-related conditions and controls without the corresponding condition. The matched cohorts were: 1) patients with epilepsy and controls (N\u200a=\u200a67,825 matched pairs); 2) patients with hemorrhage stroke and controls (N\u200a=\u200a81,510 matched pairs); 3) patients with MS and controls (N\u200a=\u200a9,853 matched pairs); and 4) patients TBI and controls (N\u200a=\u200a104,637 matched pairs). We used the Cox model to investigate the associations between neuroinflammation-related conditions and AD. Results: We identified that epilepsy, hemorrhage stroke, and TBI were associated with increased risks of AD in both males and females (hazard ratios [HRs]\u22651.74, p\u200a&lt;\u200a0.001), as well as in gender- and race-conscious subpopulations (HRs\u22651.64, p\u200a&lt;\u200a0.001). We identified that MS was associated with increased risks of AD in both males and females (HRs\u22651.47, p\u22640.004), while gender- and race-conscious subgroup analysis shown mixed associations. Conclusions: Patients with epilepsy, hemorrhage stroke, MS, and\/or TBI are associated with a higher risk of developing AD. More attention on cognitive status should be given to older patients with these conditions.<\/jats:p>","DOI":"10.3233\/jad-231286","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T12:20:50Z","timestamp":1714738850000},"page":"739-752","source":"Crossref","is-referenced-by-count":3,"title":["Associations Between Neuroinflammation-Related Conditions and Alzheimer\u2019s Disease: A Study of US Insurance Claims Data"],"prefix":"10.1177","volume":"99","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuedi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malaz","family":"Boustani","sequence":"additional","affiliation":[{"name":"Indiana University Center for Health Innovation and Implementation Science, School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-231286_ref1","doi-asserted-by":"crossref","unstructured":"(2022) 2022 Alzheimer\u2019s disease facts and figures. 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