{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:59Z","timestamp":1777397039135,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms (NPS) in patients with dementia lead to caregiver burdens and worsen the patient\u2019s prognosis. Although many neuroimaging studies have been conducted, the etiology of NPS remains complex. We hypothesize that brain structural asymmetry could play a role in the appearance of NPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study explores the relationship between NPS and brain asymmetry in patients with Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Demographic and MRI data for 121 mild AD cases were extracted from a multicenter Japanese database. Brain asymmetry was assessed by comparing the volumes of gray matter in the left and right brain regions. NPS was evaluated using the Neuropsychiatric Inventory (NPI). Subsequently, a comprehensive assessment of the correlation between brain asymmetry and NPS was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among each NPS, aggressive NPS showed a significant correlation with asymmetry in the frontal lobe, indicative of right-side atrophy (\n                      <jats:italic>r<\/jats:italic>\n                      \u200a=\u200a0.235,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.009). This correlation remained statistically significant even after adjustments for multiple comparisons (\n                      <jats:italic>p<\/jats:italic>\n                      \u200a&lt;\u200a0.01). Post-hoc analysis further confirmed this association (\n                      <jats:italic>p<\/jats:italic>\n                      \u200a&lt;\u200a0.05). In contrast, no significant correlations were found for other NPS subtypes, including affective and apathetic symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study suggests frontal lobe asymmetry, particularly relative atrophy in the right hemisphere, may be linked to aggressive behaviors in early AD. These findings shed light on the neurobiological underpinnings of NPS, contributing to the development of potential interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231306","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T11:34:00Z","timestamp":1708688040000},"page":"539-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Examining Frontal Lobe Asymmetry and Its Potential Role in Aggressive Behaviors in Early Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"98","author":[{"given":"Hiroshi","family":"Kameyama","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tagai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kashibayashi","sequence":"additional","affiliation":[{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Kindai University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kazui","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kochi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"PrinceM WimoA AliGC WuYT PrinaM(2015) World Alzheimer Report 2015. 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