{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:45Z","timestamp":1777397025120,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:p>Background: Dementia is prevalent among the elderly, also representing a risk for seizures\/epilepsy. Estimations of epilepsy risk in dementia patients are not widely available. Objective: Our research aims to ascertain the incidence of epilepsy and its associated risk factors in subjects with dementia in the Umbria region, based on data from healthcare databases. Methods: In this retrospective study based on the healthcare administrative database of Umbria, we identified all patients diagnosed with dementia from 2013 to 2017, based on ICD-9-CM codes. For epilepsy ascertainment, we used a validated algorithm that required an EEG and the prescription of one or more anti-seizure medications post-dementia diagnosis. A case-control analysis was conducted, matching five non-dementia subjects by gender and age to each dementia patient. Cox proportional hazards models were then utilized in the analysis. Results: We identified 7,314 dementia cases, also including 35,280 age- and sex-matched control subjects. Out of patients with dementia, 148 individuals (2.02%) were diagnosed with epilepsy. We observed a progressive increase in the cumulative incidence of seizures over time, registering 1.45% in the first year following the diagnosis, and rising to 1.96% after three years. Analysis using Cox regression revealed a significant association between the development of epilepsy and dementia (HR\u200a=\u200a4.58, 95% CI\u200a=\u200a3.67\u20135.72). Additional risk factors were male gender (HR\u200a=\u200a1.35, 95% CI\u200a=\u200a1.07\u20131.69) and a younger age at dementia onset (HR\u200a=\u200a1.03, 95% CI=1.02-1.04). Conclusions: Dementia increases epilepsy risk, especially with early onset and male gender. Clinicians should have a low threshold to suspect seizures in dementia cases.<\/jats:p>","DOI":"10.3233\/jad-231309","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T10:34:49Z","timestamp":1712658889000},"page":"1533-1542","source":"Crossref","is-referenced-by-count":2,"title":["Incidence and Risk Factors Epilepsy in Patients with Dementia: A Population-Based Study Using Regional Healthcare Databases in Umbria"],"prefix":"10.1177","volume":"98","author":[{"given":"Cinzia","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Nardi Cesarini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy"},{"name":"UOC Neurologia, Ospedali Riuniti Marche Nord, Fano-Pesaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Franchini","sequence":"additional","affiliation":[{"name":"Health ICT Service, Regional Health Authority of Umbria, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Casucci","sequence":"additional","affiliation":[{"name":"Health ICT Service, Regional Health Authority of Umbria, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello F.","family":"De Giorgi","sequence":"additional","affiliation":[{"name":"Health ICT Service, Regional Health Authority of Umbria, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Calvello","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy"},{"name":"UOC Neurologia, SM Goretti, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Paolini Paoletti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. Misericordia Hospital, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neurology Clinic, University of Perugia, S.M. 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