{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:26Z","timestamp":1777397006350,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lifestyle factors are linked to differences in brain aging and risk for Alzheimer\u2019s disease, underscored by concepts like \u2018cognitive reserve\u2019 and \u2018brain maintenance\u2019. The Resilience Index (RI), a composite of 6 factors (cognitive reserve, physical and cognitive activities, social engagement, diet, and mindfulness) provides such a holistic measure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to examine the association of RI scores with cognitive function and assess the mediating role of cortical atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Baseline data from 113 participants (aged 45+, 68% female) from the Healthy Brain Initiative were included. Life course resilience was estimated with the RI, cognitive performance with Cognivue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , and brain health using a machine learning derived Cortical Atrophy Score (CAS). Mediation analysis probed the relationship between RI, cognitive outcomes, and cortical atrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In age and sex adjusted models, the RI was significantly associated with CAS (\u03b2=\u200a\u20130.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a=\u200a0.006) and Cognivue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      scores (\u03b2=\u200a0.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a&lt;\u200a0.001). The RI-Cognivue\n                      <jats:sup>\u00ae<\/jats:sup>\n                      association was partially mediated by CAS (\u03b2=\u200a0.07; 95% CI [0.02, 0.14]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Findings revealed that the collective effect of early and late-life lifestyle resilience factors on cognition are partially explained by their association with less brain atrophy. These findings underscore the value of comprehensive lifestyle assessments in understanding the risk and progression of cognitive decline and Alzheimer\u2019s disease in an aging population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231346","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:03:26Z","timestamp":1710504206000},"page":"1017-1027","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Mediating Role of Cortical Atrophy on the Relationship between the Resilience Index and Cognitive Function: Findings from the Healthy Brain Initiative"],"prefix":"10.1177","volume":"98","author":[{"given":"Deirdre M.","family":"O\u2019Shea","sequence":"first","affiliation":[{"name":"Department of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, FL, 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