{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:17:05Z","timestamp":1777393025444,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A range of imaging modalities have reported Alzheimer\u2019s disease-related abnormalities in individuals experiencing subjective cognitive decline (SCD). However, there has been no consistent local abnormality identified across multiple neuroimaging modalities for SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the convergent local alterations in amyloid-\u03b2 (A\u03b2) deposition, glucose metabolism, and resting-state functional MRI (RS-fMRI) metrics in SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fifty SCD patients (66.4\u00b15.7 years old, 19 men [38%]) and 15 normal controls (NC) (66.3\u00b14.4 years old, 5 men [33.3%]) were scanned with both [\n                      <jats:sup>18<\/jats:sup>\n                      F]-florbetapir PET and [\n                      <jats:sup>18<\/jats:sup>\n                      F]-fluorodeoxyglucose PET, as well as simultaneous RS-fMRI from February 2018 to November 2018. Voxel-wise metrics were retrospectively analyzed, including A\u03b2 deposition, glucose metabolism, amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality(DC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The SCD group showed increased A\u03b2 deposition and glucose metabolism ( p\u200a&lt;\u200a0.05, corrected), as well as decreased ALFF, ReHo, and DC ( p\u200a&lt;\u200a0.05, uncorrected) in the left dorsal precuneus (dPCu). Furthermore, the dPCu illustrated negative resting-state functional connectivity with the default mode network. Regarding global A\u03b2 deposition positivity, the A\u03b2 deposition in the left dPCu showed a gradient change, i.e., A\u03b2 positive SCD\u200a&gt;\u200aA\u03b2 negative SCD\u200a&gt;\u200aA\u03b2 negative NC. Additionally, both A\u03b2 positive SCD and A\u03b2 negative SCD showed increased glucose metabolism and decreased RS-fMRI metrics in the dPCu.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The dorsal precuneus, an area implicated in early AD, shows convergent neuroimaging alterations in SCD, and might be more related to other cognitive functions (e.g., unfocused attention) than episodic memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231360","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:08:00Z","timestamp":1724753280000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline"],"prefix":"10.1177","volume":"101","author":[{"given":"Xuan-Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China"},{"name":"Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China"},{"name":"Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China"},{"name":"Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Chang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Fei","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ying","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Zang","sequence":"additional","affiliation":[{"name":"Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China"},{"name":"Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China"},{"name":"Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China"},{"name":"Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China"},{"name":"School of Biomedical Engineering, Hainan University, Haikou, China"},{"name":"Center of Alzheimer\u2019s Disease, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"National Clinical Research Center for 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