{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:52Z","timestamp":1787025892861,"version":"build-2736575974"},"reference-count":67,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:p>Background: Histopathologic studies of Alzheimer\u2019s disease (AD) suggest that extracellular amyloid-\u03b2 (A\u03b2) plaques promote the spread of neurofibrillary tau tangles. However, these two proteinopathies initiate in spatially distinct brain regions, so how they interact during AD progression is unclear. Objective: In this study, we utilized A\u03b2 and tau positron emission tomography (PET) scans from 572 older subjects (476 healthy controls (HC), 14 with mild cognitive impairment (MCI), 82 with mild AD), at varying stages of the disease, to investigate to what degree tau is associated with cortical A\u03b2 deposition. Methods: Using multiple linear regression models and a pseudo-longitudinal ordering technique, we investigated remote tau-A\u03b2 associations in four pathologic phases of AD progression based on tau spread: 1) no-tau, 2) pre-acceleration, 3) acceleration, and 4) post-acceleration. Results: No significant tau-A\u03b2 association was detected in the no-tau phase. In the pre-acceleration phase, the earliest stage of tau deposition, associations emerged between regional tau in medial temporal lobe (MTL) (i.e., entorhinal cortex, parahippocampal gyrus) and cortical A\u03b2 in lateral temporal lobe regions. The strongest tau-A\u03b2 associations were found in the acceleration phase, in which tau in MTL regions was strongly associated with cortical A\u03b2 (i.e., temporal and frontal lobes regions). Strikingly, in the post-acceleration phase, including 96% of symptomatic subjects, tau-A\u03b2 associations were no longer significant. Conclusions: The results indicate that associations between tau and A\u03b2 are stage-dependent, which could have important implications for understanding the interplay between these two proteinopathies during the progressive stages of AD.<\/jats:p>","DOI":"10.3233\/jad-231362","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T12:40:52Z","timestamp":1711716052000},"page":"1467-1482","source":"Crossref","is-referenced-by-count":6,"title":["Remote Associations Between Tau and Cortical Amyloid-\u03b2 Are Stage-Dependent"],"prefix":"10.1177","volume":"98","author":[{"given":"Seyed Hani","family":"Hojjati","sequence":"first","affiliation":[{"name":"Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria C.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Brain Health Imaging Institute, Weill Cornell 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