{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:17:29Z","timestamp":1777393049217,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,9,24]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The association of moderate and severe dementia with low body mass index (BMI) is well described, but weight decline seems to also occur in individuals with preclinical neuropathologies. Considering that up to one-fifth of individuals with normal cognition meet the criteria for a dementia-related neuropathological diagnosis, autopsy studies are key to detecting preclinical neurodegenerative and cerebrovascular diseases that could be underlying weight changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated the association between dementia-related brain lesions and BMI and evaluated whether the cognitive function was a mediator of this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In 1,170 participants, sociodemographic data, clinical history, and cognitive post-mortem evaluation were assessed with an informant. Neuropathological evaluation was performed in all cases. Linear regression models were used to investigate the association between neuropathological lesions (exposure variable) and BMI (outcome) adjusted for demographic, clinical, and cognitive variables in the whole sample, and in only those with normal cognition. Corrections for multiple comparisons were performed. In addition, a mediation analysis was performed to investigate the direct and indirect effects of cognitive abilities on the association between neuropathology and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Individuals with lower BMI had a higher burden of neuropathological lesions and poorer cognitive abilities. Only neurofibrillary tangles (NFT) and neuropathological comorbidity were associated with low BMI, while other neurodegenerative and cerebrovascular lesions were not. NFT were indirectly associated with BMI through cognitive abilities, and also directly, even in participants with normal cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Neurofibrillary tangles were directly associated with low BMI even in individuals with preclinical Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231366","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:13:34Z","timestamp":1725016414000},"page":"773-785","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Neuropathological Lesions and Body Mass Index Is Independent of Cognitive Abilities"],"prefix":"10.1177","volume":"101","author":[{"given":"Raul dos Reis","family":"Ururahy","sequence":"first","affiliation":[{"name":"Division of Geriatrics \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica no Envelhecimento (LIM 66), University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Scott","family":"do Val","sequence":"additional","affiliation":[{"name":"Escola Polit\u00e9cnica of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Maria Macagnan","family":"Ciciliati","sequence":"additional","affiliation":[{"name":"Division of Geriatrics \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica no Envelhecimento (LIM 66), University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Elaine Paraizo","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor Ribeiro","family":"Paes","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Diehl","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea Tenenholz","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos 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