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Identification and validation of biomarkers that herald the onset and progression of Alzheimer\u2019s disease is of paramount importance for early reliable diagnosis and effective pharmacological therapy commencement. A substantial body of evidence has emerged demonstrating that olfactory dysfunction is a preclinical symptom of neurodegenerative diseases including Alzheimer\u2019s disease. While a correlation between olfactory dysfunction and Alzheimer\u2019s disease onset and progression in humans exists, the mechanism underlying this relationship remains unknown. The aim of this article is to review the current state of knowledge regarding the range of potential factors that may contribute to the development of Alzheimer\u2019s disease-related olfactory dysfunction. This review predominantly focuses on genetic mutations associated with Alzheimer\u2019s disease including amyloid-\u03b2 protein precursor, presenilin 1 and 2, and apolipoprotein E mutations, that may (in varying ways) drive the cellular events that lead to and sustain olfactory dysfunction.<\/jats:p>","DOI":"10.3233\/jad-231377","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T11:39:27Z","timestamp":1715341167000},"page":"811-827","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Olfactory Dysfunction and Alzheimer\u2019s Disease: A Review"],"prefix":"10.1177","volume":"99","author":[{"given":"Alexandra M.R.","family":"McLaren","sequence":"first","affiliation":[{"name":"Centre for Neuroscience Studies, Queen\u2019s University, Kingston, Ontario, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Kawaja","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience Studies, Queen\u2019s University, Kingston, Ontario, ON, Canada"},{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref004","unstructured":"Statistics Canada. 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