{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:52Z","timestamp":1787025892897,"version":"build-2736575974"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:p>Impairments of the sleep architecture due to disrupted sleep in individuals with obstructive sleep apnea (OSA) may result in reduced slow wave sleep (SWS), intermittent hypoxemia, and excessive day time sleepiness\u2014 all factors that have been shown to impact Alzheimer\u2019s disease (AD) risk. In this commentary, we comment on the work by Cavuoto and colleagues in which they examine the associations between nocturnal hypoxemia or sleep disruptions (during SWS) and amyloid-\u03b2 burden in individuals with OSA. We review the findings in the context of other similar studies and highlight the strengths and weaknesses of these published studies. We note the importance of examining these relationships longitudinally with a large sample size, including considering sleep health disparities, vascular components, and multiple cognitive domain tests.<\/jats:p>","DOI":"10.3233\/jad-231385","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:45:15Z","timestamp":1708080315000},"page":"69-73","source":"Crossref","is-referenced-by-count":8,"title":["Obstructive Sleep Apnea and Alzheimer\u2019s Disease Pathology: Is Sleep Architecture the Missing Key?"],"prefix":"10.1177","volume":"98","author":[{"given":"Joshua L.","family":"Gills","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Healthy Brain Aging Sleep Center, NYU Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Population Health, Institute of Excellence in Health Equity, Center for Healthful Behavior Change, NYU Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omonigho M.","family":"Bubu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Healthy Brain Aging Sleep Center, NYU Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Population Health, Institute of Excellence in Health Equity, Center for Healthful Behavior Change, NYU Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Neurology, NYU Alzheimer\u2019s Disease Research Center, Center for Cognitive Neurology, NYU Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Neuroscience and Physiology, NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-231385_ref1","doi-asserted-by":"crossref","first-page":"zsz048","DOI":"10.1093\/sleep\/zsz048","article-title":"Obstructive sleep apnea and longitudinal Alzheimer\u2019s disease biomarker changes","volume":"42","author":"Bubu","year":"2019","journal-title":"Sleep"},{"key":"10.3233\/JAD-231385_ref2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1164\/rccm.201704-0704OC","article-title":"Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly. 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