{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:18Z","timestamp":1777396938518,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:p>Background: While many studies focus on the prognosis of individual neurological diseases, very few comprehensively compare and analyze real-world data of these diseases. Objective: To address this gap in knowledge, in this study, we comprehensively analyzed the real-life data of patients with neurological diseases. Methods: We prospectively enrolled patients with neurological diseases at three hospitals from December 1, 2016 to September 30, 2020. Neurological diseases were classified into nine groups: Dementia, Cerebrovascular disease, Parkinson\u2019s and related, Functional, Spinocerebellar degeneration, Neuroimmune, Epilepsy, Muscle dystrophy disease, and Hypertension. Patients were followed up for three years, and their prognosis and evaluation of their cognitive function served as the endpoint. Results: A total of 426 patients were finally enrolled. Both mortality and cognitive function differed among the neurological disease categories. After 3 years, mortality was highest in the Dementia (25.5%), Parkinson\u2019s and related (21.6%), and Spinocerebellar degeneration (35.3%) groups while the cognitive function of patients in these three groups was significantly lowest. Conclusions: When the neurological diseases were holistically observed, both mortality and cognitive function of the Dementia, Parkinson\u2019s and related, and Spinocerebellar degeneration groups were significantly worse than the remaining diseases.<\/jats:p>","DOI":"10.3233\/jad-231390","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:22:13Z","timestamp":1708428133000},"page":"275-285","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Prognosis and Cognitive Function of Holistic Neurological Disease: Tochigi Neurological Disease Cohort Study"],"prefix":"10.1177","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-3903","authenticated-orcid":false,"given":"Kosuke","family":"Matsuzono","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Neurology, Jichi Medical University, Tochigi, Japan"},{"name":"Department of Medicine, Kamitsuga General Hospital, Tochigi, Japan"},{"name":"Department of Internal Medicine, Imai Hospital, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Mashiko","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology, Jichi Medical University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology, Jichi Medical University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yoshizumi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kamitsuga General Hospital, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology, Jichi Medical University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-231390_ref1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11845-018-1858-2","article-title":"Dementia-a major public health problem: The role of in-patient psychiatric facilities","volume":"188","author":"Daly","year":"2019","journal-title":"Ir J Med Sci"},{"key":"10.3233\/JAD-231390_ref2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/ggi.13716","article-title":"Social determinants of the association among cerebrovascular disease, hearing loss and cognitive impairment in a middle-aged or older population: Recurrent neural network analysis of the Korean Longitudinal Study of Aging (2014\u20132016)","volume":"19","author":"Lee","year":"2019","journal-title":"Geriatr Gerontol Int"},{"key":"10.3233\/JAD-231390_ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12877-022-03028-0","article-title":"Patterns of dementia treatment in older adults with Parkinson\u2019s disease using nationwide medical claims data","volume":"22","author":"Yoon","year":"2022","journal-title":"BMC Geriatr"},{"key":"10.3233\/JAD-231390_ref4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J Parkinsons Dis"},{"key":"10.3233\/JAD-231390_ref5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s12877-021-02540-z","article-title":"Future projections of the prevalence of dementia in Japan: Results from the Toyama Dementia Survey","volume":"21","author":"Nakahori","year":"2021","journal-title":"BMC Geriatr"},{"key":"10.3233\/JAD-231390_ref6","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1001\/jama.291.22.2734","article-title":"Estimating prognosis for nursing home residents with advanced dementia","volume":"291","author":"Mitchell","year":"2004","journal-title":"JAMA"},{"key":"10.3233\/JAD-231390_ref7","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1007\/s10072-022-06377-1","article-title":"Real-time data on the prognosis of acute ischemic stroke patients in the Tochigi Clinical ObservatioNal registry for 1-year mortality of aCute ischEmic stRoke patieNt (T-CONCERN) study","volume":"43","author":"Matsuzono","year":"2022","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-231390_ref8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000113485","article-title":"Prognosis of Parkinson\u2019s disease in Japan. 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