{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:26Z","timestamp":1777397006535,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The impairment of neural circuits controlling cognitive processes has been implicated in the pathophysiology of Alzheimer\u2019s disease and related disorders (ADRD). However, it is largely unclear what circuits are specifically changed in ADRD, particularly at the early stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our goal of this study is to reveal the functional changes in the circuit of entorhinal cortex (EC), an interface between neocortex and hippocampus, in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Electrophysiological, optogenetic and chemogenetic approaches were used to examine and manipulate entorhinal cortical circuits in amyloid-\u03b2 familial AD model (5\u00d7FAD) and tauopathy model (P301S Tau).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that, compared to wild-type mice, electrical stimulation of EC induced markedly smaller responses in subiculum (hippocampal output) of 5\u00d7FAD mice (6-month-old), suggesting that synaptic communication in the EC to subiculum circuit is specifically blocked in this AD model. In addition, optogenetic stimulation of glutamatergic terminals from prefrontal cortex (PFC) induced smaller responses in EC of 5\u00d7FAD and P301S Tau mice (6-month-old), suggesting that synaptic communication in the PFC to EC pathway is compromised in both ADRD models. Chemogenetic activation of PFC to EC pathway did not affect the bursting activity of EC neurons in 5\u00d7FAD mice, but partially restored the diminished EC neuronal activity in P301S Tau mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These data suggest that 5\u00d7FAD mice has a specific impairment of short-range hippocampal gateway (EC to subiculum), which may be caused by amyloid-\u03b2 deposits; while two ADRD models have a common impairment of long-range cortical to hippocampal circuit (PFC to EC), which may be caused by microtubule\/tau-based transport deficits. These circuit deficits provide a pathophysiological basis for unique and common impairments of various cognitive processes in ADRD conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-231413","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:03:37Z","timestamp":1710504217000},"page":"1121-1131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct and Convergent Alterations of Entorhinal Cortical Circuits in Two Mouse Models for Alzheimer\u2019s Disease and Related Disorders"],"prefix":"10.1177","volume":"98","author":[{"given":"Ping","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac036"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc8096"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28493-4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306110"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720508785132280"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-85"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00266"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2019"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3085"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01092-3"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.07.002"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.002"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4661"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4327"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00170"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.74"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1178"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804766-8.00013-3"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.07.002"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.04.007"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-27977-7"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.08.003"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/381243"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.05.006"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22547"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5694"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.11.034"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210125"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1028"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450010410"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00446.x"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.10.003"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20220"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2018.08.002"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00054-X"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.03.003"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep42370"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.020"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.056796"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3606"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35749-6"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy354"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13456"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0165-6"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa027"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0498-x"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108874"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5298-07.2008"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu190"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.06.014"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26972-8"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0149-18.2018"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01574-y"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx104"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.012"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.04.013"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1535-7511.2005.00049.x"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68795"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-231413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:43Z","timestamp":1777370983000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-231413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.3233\/JAD-231413"],"URL":"https:\/\/doi.org\/10.3233\/jad-231413","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]}}}