{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:15:23Z","timestamp":1777396523949,"version":"3.51.4"},"reference-count":157,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a neurodegenerative condition that displays a high prevalence in Lebanon causing a local burden in healthcare and socio-economic sectors. Unfortunately, the lack of prevalence studies and clinical trials in Lebanon minimizes the improvement of AD patient health status. In this review, we include over 155 articles to cover the different aspects of AD ranging from mechanisms to possible treatment and management tools. We highlight some important modifiable and non-modifiable risk factors of the disease including genetics, age, cardiovascular diseases, smoking, etc. Finally, we propose a hypothetical genetic synergy model between\n                    <jats:italic>APOE4<\/jats:italic>\n                    and\n                    <jats:italic>TREM2<\/jats:italic>\n                    genes which constitutes a potential early diagnostic tool that helps in reducing the risk of AD based on preventative measures decades before cognitive decline. The studies on AD in Lebanon and the Middle East are scarce. This review points out the importance of genetic mapping in the understanding of disease pathology which is crucial for the emergence of novel diagnostic tools. Hence, we establish a rigid basis for further research to identify the most influential genetic and environmental risk factors for the purpose of using more specific diagnostic tools and possibly adopting a local management protocol.\n                  <\/jats:p>","DOI":"10.3233\/jad-231432","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:17:24Z","timestamp":1713269844000},"page":"21-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Alzheimer\u2019s Disease in Lebanon: Exploring Genetic and Environmental Risk Factors\u2014A Comprehensive Review"],"prefix":"10.1177","volume":"99","author":[{"given":"Mohamad","family":"Khaled","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Al-Jamal","sequence":"additional","affiliation":[{"name":"Faculty of Public Health III, Lebanese University, Tripoli, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layla","family":"Tajer","sequence":"additional","affiliation":[{"name":"Faculty of Public Health III, Lebanese University, Tripoli, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"El-Mir","sequence":"additional","affiliation":[{"name":"Faculty of Public Health III, Lebanese University, Tripoli, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.96"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190654"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000512"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000687"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.12.007"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2020.103514"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0459-7"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.01.010"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30403-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.38"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2022-100751"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1748796"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-019-0074-y"},{"key":"e_1_3_4_20_2","first-page":"2133","article-title":"Epidemiology and risk factors of Alzheimer\u2019s disease in Iran: A systematic review","volume":"48","author":"Navipour E","year":"2019","unstructured":"NavipourE, NeamatshahM, BarabadiZ, NeamatshahM, KeykhosraviA (2019) Epidemiology and risk factors of Alzheimer\u2019s disease in Iran: A systematic review. Iran J Public Health 48, 2133\u20132139.","journal-title":"Iran J Public Health"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.npg.2014.05.003"},{"key":"e_1_3_4_22_2","first-page":"21","article-title":"Spot light on Alzheimer\u2019s disease in the North Lebanon","volume":"1","author":"Khaled M","year":"2010","unstructured":"KhaledM (2010) Spot light on Alzheimer\u2019s disease in the North Lebanon. Middle East J Psychiatry Alzheimers 1, 21\u201337.","journal-title":"Middle East J Psychiatry Alzheimers"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.04.007"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0313-y"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124477"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.35"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02057.x"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2362"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012025"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa223"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0557-6"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4443"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181106"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157931"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018838"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01961-8"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15269"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000585"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108352"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx047"},{"key":"e_1_3_4_42_2","unstructured":"Alzheimer\u2019s Association (2022) More than normal aging: Understanding mild cognitive impairment.https:\/\/www.alz.org\/media\/Documents\/alzheimers-facts-and-figures-special-report-2022.pdf."},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.05.013"},{"key":"e_1_3_4_44_2","first-page":"e12016","article-title":"In vivo network models identify sex differences in the spread of tau pathology across the brain","volume":"12","author":"Shokouhi S","year":"2020","unstructured":"ShokouhiS, TaylorWD, AlbertK, KangH, NewhousePA, The Alzheimer\u2019s Disease Neuroimaging Initiative (2020) In vivo network models identify sex differences in the spread of tau pathology across the brain. Alzheimers Dement (Amst) 12, e12016.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0524-y"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.046149"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3934\/Neuroscience.2021021"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.10.008"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0130-5"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041505"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-15412"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab208"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00508"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113306"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.12816\/0042966"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0465-5"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021659"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.01.004"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201096"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190249"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.11.005"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-017-1604-y"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070725"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22090"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030923"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-2455-2"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180564"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16970"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01210-1"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.6027"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12035"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0791-z"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149945"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-137"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4361-12.2013"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.644213"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13281"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.013"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16622"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-99"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006296"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00108"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.024"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_473_17"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00921-z"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.270108"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.1.43"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00427"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0856-8"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200598"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S85808"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2019.02.005"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S350939"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554-10.2010"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.03.014"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01677-0"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-014-0034-x"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-021-00819-9"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/254954"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132450"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317516679303"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874609812666191019143237"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060871"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.07.003"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018569"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1299-4"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4365"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00681-8"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1159\/000321984"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2018-0067"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-35"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-2"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.4215"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00234-5"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001160"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.630502"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.04.010"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009093"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2620-14.2015"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01878-2"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142322"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19227-5"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041611"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0296-9"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.679043"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0835-4"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6237"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.049"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu277"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0016-9"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0051-1"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2019.05.007"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02049-x"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4654"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12369"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02408-5"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267407"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58010060"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13999-0"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.853294"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321913"},{"key":"e_1_3_4_144_2","unstructured":"PrinceM AlbaneseE GuerchetM PrinaM (2014) World Alzheimer Report 2014. Dementia and Risk Reduction: An analysis of protective and modifiable risk factors. Alzheimer\u2019s Disease International London UK."},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1530"},{"key":"e_1_3_4_146_2","first-page":"CD010783","article-title":"Mini-Mental State Examination (MMSE) for the detection of Alzheimer\u2019s disease and other dementias in people with mild cognitive impairment (MCI)","volume":"2015","author":"Arevalo-Rodriguez I","year":"2015","unstructured":"Arevalo-RodriguezI, SmailagicN, Roqu\u00e9 FigulsIM, CiapponiA, Sanchez-PerezE, GiannakouA, PedrazaOL, Bonfill CospX, CullumS (2015) Mini-Mental State Examination (MMSE) for the detection of Alzheimer\u2019s disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2015, CD010783.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198610000-00005"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.06.004"},{"key":"e_1_3_4_149_2","doi-asserted-by":"crossref","unstructured":"TerwilligerJD (2022) Gene mapping and human disease. In Genetics of Substance Use: Research and Clinical Aspects. Springer pp. 147-175.","DOI":"10.1007\/978-3-030-95350-8_6"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012067"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120166"},{"key":"e_1_3_4_152_2","first-page":"739","article-title":"ApoE4-induced cholesterol dysregulation and its brain cell type-specific implications in the pathogenesis of Alzheimer\u2019s disease","volume":"42","author":"Jeong W","year":"2019","unstructured":"JeongW, LeeH, ChoS, SeoJ (2019) ApoE4-induced cholesterol dysregulation and its brain cell type-specific implications in the pathogenesis of Alzheimer\u2019s disease. Mol Cells 42, 739\u2013746.","journal-title":"Mol Cells"},{"key":"e_1_3_4_153_2","first-page":"3","article-title":"Oxidative stress mediates the pathogenic effect of different Alzheimer\u2019s disease risk factors","volume":"2","author":"Guglielmotto M","year":"2010","unstructured":"GuglielmottoM, GilibertoL, TamagnoE, TabatonM (2010) Oxidative stress mediates the pathogenic effect of different Alzheimer\u2019s disease risk factors. Front Aging Neurosci 2, 3.","journal-title":"Front Aging Neurosci"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-46"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02200-3"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150778"},{"key":"e_1_3_4_157_2","first-page":"71","article-title":"Apolipoprotein E4 allele frequency in young Africans of Ugandan descent versus African Americans","volume":"95","author":"Willis F","year":"2003","unstructured":"WillisF, Graff-RadfordN, PintoM, LawsonL, EpsteinD, ParfittF, HuftonM, O\u2019BrienPC (2003) Apolipoprotein E4 allele frequency in young Africans of Ugandan descent versus African Americans. J Natl Med Assoc 95, 71\u201376.","journal-title":"J Natl Med Assoc"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.84"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-231432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:30Z","timestamp":1777370910000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-231432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":157,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,4,30]]}},"alternative-id":["10.3233\/JAD-231432"],"URL":"https:\/\/doi.org\/10.3233\/jad-231432","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}